This prospective multicenter validation study aimed to evaluate the predictive performance of a previously developed model for MDRGNB infection in ICU patients.
Age ≥18 years;
ICU stay ≥48 hours;
At least one clinical microbiological specimen collected and submitted for testing within 48 hours of ICU admission, with the first submission time designated as the index time;
Core predictive variables of the model extractable from electronic medical records or laboratory information systems.
For patients with multiple ICU admissions, only the first ICU stay was retained;
Missing or indeterminate primary outcome;
Missing key predictive variables that could not be handled according to prespecified rules.
Adult ICU patients
Cohort
Cross-sectional
Not listed
MDRGNB infection
The objective of this study was to observe whether enrolled patients developed early MDRGNB infection and to validate the model's performance. The occurrence of MDRGNB infection was adjudicated by integrating clinical manifestations with culture results from collected specimens.Baseline and model variables: Collected within 48 hours of ICU admission.Primary outcome: Determined based on the results of the first submitted specimen.
28-day mortality
28-day mortality
Sequential Organ Failure Assessment (SOFA) score at 48 hours
SOFA score at 48 hours, higher SOFA score mean a worse outcome
Adverse events related to antibiotic within 28 days
Adverse events related to antibiotic within 28 days, defined by Naranjo scale.
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The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Lead sponsor
Ruijin Hospital
Collaborator
Zhejiang Hospital
Collaborator
