Multimodal Nutritional and Sarcopenia Assessment for Risk Stratification in Lung Cancer Surgery
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorOndokuz Mayıs University
About this trial
This prospective observational cohort study aims to evaluate the prognostic value of multimodal nutritional status and sarcopenia assessment in patients undergoing lung cancer surgery. Postoperative complications, mortality, and prolonged hospital stay remain major clinical concerns in thoracic surgery. Although malnutrition and sarcopenia are recognized as important determinants of surgical outcomes, their combined and multidimensional evaluation has not been sufficiently studied.
Adult patients undergoing anatomical lung resection for primary lung cancer will be included. Nutritional status will be assessed using serum biomarkers, inflammatory indices, and validated clinical nutritional scores. Sarcopenia will be evaluated using computed tomography-based muscle mass and density measurements, as well as ultrasonographic muscle thickness.
These parameters will be analyzed in relation to postoperative complications, intensive care unit (ICU) requirement, length of hospital stay, and mortality. Multivariable analyses will be performed to identify independent predictors, and a combined risk stratification model will be developed.
This study aims to improve preoperative risk assessment and to support personalized perioperative management strategies, including identification of patients who may benefit from targeted nutritional optimization and prehabilitation.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age ≥18 years
Patients undergoing anatomical lung resection (lobectomy or segmentectomy) for primary lung cancer
Availability of preoperative thoracic computed tomography (CT) within 30 days before surgery
Completion of preoperative nutritional assessment and ultrasonographic muscle measurements
Disqualifiers
Receipt of neoadjuvant chemotherapy, immunotherapy, or radiotherapy
Emergency surgery
Pneumonectomy
Combined resection of another organ during the same procedure
Trial population
Adult patients undergoing anatomical lung resection (lobectomy or segmentectomy) for primary lung cancer at a tertiary thoracic surgery center will be included. All participants will be prospectively enrolled and evaluated preoperatively for nutritional status and sarcopenia using clinical, biochemical, and imaging-based assessments.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Observational Assessment
Other interventionParticipants will undergo standard preoperative clinical evaluation including nutritional assessment, laboratory measurements, and imaging-based body composition analysis as part of routine care. No experimental intervention or treatment is administered. All data are collected observationally without influencing clinical management.
Treatment groups
142 Participants
are divided into 1 treatment groupGroup A: Lung Cancer Surgery Cohort1 intervention
Trial outcomes
Primary outcomes
1
Postoperative complications (30-day, Clavien-Dindo classification)
Occurrence of postoperative complications within 30 days after surgery, classified according to the Clavien-Dindo classification system. Major complications are defined as Grade III or higher. This outcome will be analyzed as both overall complication rate and major complication rate.
Time frame
Within 30 days after surgerySecondary outcomes
1
Length of hospital stay
Total number of days from the date of surgery to hospital discharge.
Time frame
Postoperative period (up to 30 days)Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov