Multiomics Study of Biological Behavior of Lymph Node Metastasis in Papillary Thyroid Carcinoma

ConditionsPapillary Thyroid Carcinoma Lymph Node Cancer Metastatic

Trial statusNot yet recruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18-80

SponsorTianhan Zhou

About this trial

Establish a predictive model for assessing neck lymph node metastasis of papillary thyroid carcinoma based on metabolomics, proteomics, and imaging omics data, exploring an ideal protocal for the precise diagnosis and treatment of papillary thyroid carcinoma."

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Pathological confirmation of PTC.

Patients who underwent primary surgery accompanied by central neck lymph node dissection.

Tumors measuring less than 2 cm in diameter.

Postoperative pathological reports including detailed information on the number of lymph nodes dissected and the number of metastatic lymph nodes.

Disqualifiers

Postoperative pathological diagnosis indicating sub-types of PTC.

Tumor invasion into adjacent anatomic structures such as the sternothyroid muscle, surrounding soft tissues, trachea, esophagus, or laryngeal nerve.

History of neck trauma, previous tumor surgery, or adjuvant chemoradiotherapy.

Fewer than three lymph nodes dissected during surgery.

Trial population

PTC patients underwent surgery in Hangzhou Traditional Chinese Medical Hospital

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Thy_CLNM_multi_omics
Diagnostic test
Surgery

Treatment groups

2,000 Participants

are divided into 1 treatment group

Group A: LNM group and NLNM group1 intervention

Trial outcomes

Primary outcomes

Lymph node metastasis status

Patients with thyroid cancer undergo thyroid cancer radical surgery according to the guidelines, with pathological results including the number of lymph node metastases and metastasis status, based on the final pathological diagnosis.

Time frame

Record lymph node metastasis status until the end of the surgery, followed by a one-year follow-up until the conclusion of the study.

Secondary outcomes

Surgical complications and postoperative recurrence

Hemorrhage，Infection，Recurrent laryngeal nerve injury，Hypothyroidism，Other related surgical complications and Recurrence status

Time frame

Record surgical complications until the end of the surgery, followed by a one-year follow-up until the conclusion of the study.

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Tianhan Zhou

Lead sponsor

Zhejiang Chinese Medical University

Sponsor institution

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: