This prospective study combining non conventional MRI techniques, neuropsychological screening tools, and a neurophysiological work-up using a sensitive and validated battery, will evaluate the predictive value of these measures and will explore the changes of the cognitive scores from baseline.
active MS, according to the Lublin criteria
disease duration < 10 years before initiating or changing a disease-modifying therapies,
relapse- and steroid-free for at least 1 month before MRI acquisition
between 18-50 years old
progressive forms of MS
Single group
Multiparametric assessment
Other interventionneuropsychological assessment, PRO measures, non-conventional MRI metrics
Predictors of disease evolution
EDSS score worsening from baseline
evaluation of evolutionary patterns of cognitive status (impaired vs non impaired)/changes from baseline
changes from baseline in cognitive scores
baseline predictors of future cognitive impairment
abnormal cognitive performances based on cognitive scores (using BCcogSEP battery)
alteration in strategic white matter tracts at the early stages of RRMS, in patients with and without cognitive impairment
fractional anisotropy
predictive role of mEPS in predicting future disability
the Global Evoked Potential (GEP) score at study entry (baseline); EDSS score changes from baseline
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University Hospital of Mont-Godinne
Lead sponsor
Saint-Luc University Hospital
Collaborator
