MUSCLE-ML: Multimodal Integration of Muscle Strength, Structure by Machine Learning for Precision Rehabilitation After ACL Injury

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorChinese University of Hong Kong

About this trial

The goal of this clinical trial is to use machine learning (ML) to predict functional recovery by integrating muscle-related factors and other relevant parameters for identification of non-responders to conventional rehabilitation. The main questions it aims to answer are:

Do deficit clusters lead to poorer functional recovery compared to non-deficit clusters? Does an ML-derived composite score that integrates quadriceps/hamstring strength and size outperform isolated metrics in predicting RTP success?

Researchers will compare deficit clusters against non-deficit clusters to determine if deficit clusters lead to poorer functional recovery.

Participants will:

Return for 5 follow-up timepoints in total for PRO and functional assessments including pre-operation, 1-, 3-, 6- and 12-months post-operation.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Unilateral ACL injury and plan for ACLR

Commit the post-operation physiotherapy in Prince of Wales Hospital

Disqualifiers

Preoperative radiographic signs of arthritis

Patient non-compliance to the rehabilitation program

Trial population

All the ACLR patients will be recruited at the Orthopaedics Outpatient Clinic at Prince of Wales Hospital.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • No Intervention: Observational Cohort

    Other intervention

    no intervention

Treatment groups

182 Participants
are divided into 1 treatment group
Group A: Deficit group1 intervention

Trial outcomes

Primary outcomes

1

International Knee Documentation Committee score

Time frame
6- and 12-months post-operation

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

This trial is not recruiting at the moment. You can still explore other options: