Muscle Recovery After Critical Illness

ConditionsICU Acquired Weakness Post Intensive Care Unit Syndrome Muscle Weakness Critical Illness

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexMale

Age18+

SponsorEsther Dupont-Versteegden

About this trial

The overarching goal of the proposed study is to determine the trajectories of physical recovery and cellular markers involved with the underlying failure to recover muscle after critical illness, while exploring which characteristics are associated with sustained physical disability. This proposal will examine muscle pathophysiology carefully aligned with physical function outcomes in order to longitudinally assess the recovery, or failed recovery, of muscle function in participants after critical illness:

1. to examine the recovery of muscle and physical function in ICU survivors through longitudinal assessments 2. to investigate the underlying cellular markers and mechanisms of muscle recovery in ICU survivors 3. to determine which cellular markers contribute to physical disability in ICU survivors up to 1 year after hospital admission

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

adult (>18 y/o)

admission for sepsis or acute respiratory failure with at least 72 hour stay in ICU

Disqualifiers

patients who were not ambulatory prior to ICU admission

experienced >2 ICU admissions in the past year (chronic or recurrent critical illness due to the same or different reason

patients not expected to survive ~6months after admission

acute or chronic neurologic condition

Trial population

Patients admitted to ICU for critical illness and expected to survive

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

209 Participants

are grouped into 2 trial groups

Group A: Survivor

Group B: Control

Trial outcomes