Muscle Vibration as a Countermeasure Against Hypoactivity-induced
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age19-45
SponsorCentre Hospitalier Universitaire de Saint Etienne
About this trial
Muscle deconditioning, characterized by a loss of muscle mass and strength, is a frequent consequence of prolonged lower limb unloading. Beyond muscle mass loss, reduced neural drive contributes significantly to strength decline, highlighting the need for interventions targeting neuromuscular function during immobilization. Focal muscle vibration (FMV) has shown promise in modulating neuromuscular excitability by activating muscle spindle afferents and inducing cortical adaptations. Chronic use of FMV has been associated with significant strength gains and improved neural command. This makes FMV an effective rehabilitation tool. Its simplicity and non-invasiveness further make it a practical countermeasure.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Men and women.
Aged 18 to 45 years.
Body Mass Index (BMI) between 18,5 and 24,9 kg/m².
Engaging in at least 1.5 hours per week of physical activity (e.g., brisk walking, running, swimming, cycling).
Disqualifiers
Chronic cardiovascular, neuromuscular, bone, metabolic, and/or inflammatory disorders.
Personal history and/or risk factors for thrombosis.
Use of antidepressant medications.
Use of neuroactive substances likely to alter corticospinal excitability (e.g., hypnotics, antiepileptics, psychotropics, muscle relaxants) during the study.
Trial design
Design model
Parallel
Treatments tested in this trial
Focal muscle vibration
Devicefocal muscle vibration sessions, using small and portable vibrator devices.
NO Focal muscle vibration
DeviceThe control group will not receive any intervention.
Treatment groups
42 Participants
are divided into 2 treatment groupsGroup A: VIBRATIONActive comparator 1 intervention
Group B: CONTROLESham comparator 1 intervention
Trial outcomes
Primary outcomes
1
Isometric force measurement
Maximal isometric force (% decrease) in knee extension of the immobilized leg will be evaluated
Time frame
Day 1, 7, 14, 28, 33Secondary outcomes
1
Maximum voluntary force measurement
Maximum voluntary force (Nm) in knee extension, assessed in isometric (for the immobilized leg and also for the contralateral leg), concentric (+60°/s and +180°/s) and eccentric (-60°/s) conditions.
Time frame
Day 1, 7, 14, 28, 332
Jumping performance measurement
Jumping performance (height, in cm), assessed in vertical jump tests (Squat Jump and Counter Movement Jump).
Time frame
Day 1, 7, 14, 28, 333
Postural balance measurement
Postural balance performance (displacement of center of pressure, in mm), assessed in a unipodal postural balance test performed on a strength platform
Time frame
Day 1, 7, 14, 28, 334
Neuromuscular fatigue measurement
Neuromuscular fatigue (decrease in maximum voluntary force (in %), assessed during a fatigue protocol consisting of quadriceps muscle contractions at incremental force levels.
Time frame
Day 1, 7, 14, 28, 33Sponsors and contacts
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Source ClinicalTrials.gov