NASA Exercise Prebreathe Study
ConditionDecompression Sickness
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age30-60
SponsorDuke University
About this trial
This study evaluates oxygen prebreathe protocols and exercise conditions to reduce risk of decompression sickness during simulated extravehicular activity. Healthy adult volunteers will undergo oxygen prebreathe followed by hypobaric chamber exposure with monitoring for symptoms and ultrasound detection of bubbles.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Non-smoking volunteers aged 30-60 years
Able to meet VO2 peak requirements (>35 ml/kg/min males, >30 ml/kg/min females)
Disqualifiers
Pregnancy
Lung disease, heart disease, hypertension, or diabetes
Musculoskeletal pain conditions
Requirement for regular medications such as analgesics
Trial design
Design model
Single group
Treatments tested in this trial
Oxygen Prebreathe and Hypobaric Exposure
Procedure/SurgeryPrebreathe 100% oxygen followed by simulated spacewalk conditions in hypobaric chamber with exercise protocols.
Treatment groups
30 Participants
are divided into 1 treatment groupGroup A: Single ArmExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Number of participants with Decompression Sickness
Decompression sickness will be recorded during Extravehicular Activity (EVA) simulation at 6.2 psia following a one-hour oxygen prebreathe while resting, performing light exercise or heavier exercise.
Time frame
Up to 6 monthsSponsors and contacts
Click on the lead sponsor to view all of their trials.
Duke University
Lead sponsor
National Aeronautics and Space Administration (NASA)
Collaborator
Source ClinicalTrials.gov