The goal of this randomized control trial is to assess whether nasojejunal feed is better than oral nutrition in patients who are undergoing endoscopic cystogastrostomy of walled off necrosis following acute pancreatitis. It will also try to answer, the incidence of infections and feed tolerance.
The main question it tries to answer is
1. whether nasojejunl feed is better than oral feed in patients undergoing endoscopic cystogastrostomy in walled off necrosis following acute pancreatitis 2. How much infections they develop, whether they are able to tolerate the feed, weight gain and reintervention rates in each group
Patients of acute pancreatitis (AP) with 18-75 years of age
Patients with symptomatic WON requiring EUS guided transluminal drainage
Provision of written informed consent
Patients with collection not amenable for EUS guided drainage (distance of WON >1 cm from the gastrointestinal lumen)
Known malignancy or immunocompromised state
Previous upper gastrointestinal(GI) surgery interfering with absorption
Active GI bleeding
Parallel
endoscopic ultrasonography guided cystogastrostomy
Procedure/SurgeryNasojejunal tube will be placed post EUS-CG or oral diet would be started after randomization
Nutritional failure
To compare the rate of nutritional failure at Day 14 between Nasojejunal and oral feeding post endoscopic transmural drainage of WON
Infection and new onset organ failure
To compare infection rates, need for antibiotic escalation and new onset organ failure
Re-intervention needs
To compare the need for re-intervention and hospital stay duration in either of the group
Change in weight
To compare patient weight
Inflammatory markers
To compare change in inflammatory markers (CRP, Serum Albumin)
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