Natural Course of Initially Metabolic Healthy Obese Individuals (Healthy Obesity)?
ConditionHealthy Obesity, Metabolically
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-60
SponsorETH Zurich
About this trial
The main goal of this study is to gain a thorough understanding, which specific factors drive the unhealthy sequelae of obesity. Therefore, the investigators want to understand:
1. What distinguishes obese persons without metabolic diseases from those with medical diseases in a cross-sectional comparison? 2. Which factors drive the conversions from metabolically healthy obesity into a metabolically unhealthy obesity in a longitudinal approach?
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Signed Informed Consent Form
Age between 18 and 60 years
BMI 30-50 kg/m2
Knowledge of German, which requires sufficient written and allow oral patient education
Disqualifiers
Pregnancy
Medication and / or pathologies that prevent a safe execution of the fat tissue biopsies
History of or planned bariatric operation
Medical conditions that prevent examinations and testing (e.g. symptomatic cardiovascular diseases)
Trial population
obese participants
Trial design
Design model
Case-control
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Rate of conversion
The primary endpoint is the conversion (through study completions, 10 years) from obese but metabolically healthy subjects into obese patients in a pathological metabolic state, through study completion an average of 1 year.
Time frame
Conversion will be driven by the occurrence of pathological findings caused by obesity (metabolic or cardiovascular pathologies). Through study completion, an average of 1 year.Secondary outcomes
1
Rate of identification of factors
The secondary endpoint is the identification of factors alone or in combination (through study completions, 10 years), that related to this conversion from healthy into pathological obesity. This includes factors like: DEXA scans, White Adipose Tissue, lipid and glucose metabolism, vital signs, physical activity, general health and quality of life status...
Time frame
Conversion will be driven by the occurrence of pathological findings caused by obesity (metabolic or cardiovascular pathologies), through study completion, an average of 1 year. Source ClinicalTrials.gov