Background:
Inflammatory conditions can cause symptoms like fevers, arthritis, and rash. Systemic juvenile idiopathic arthritis (sJIA) is one of these conditions. So is adult-onset Still s disease (AOSD). Their causes are unknown. Researchers want to learn more about these conditions. This includes genetic changes and environmental factors.
Objective:
To study sJIA and AOSD in children and adults over time.
Eligibility:
People with known or suspected sJIA, AOSD, or similar inflammatory condition
Design:
Participants will be screened with a phone call.
Participants will have 1 visit. It may be outpatient or they may be admitted to the clinic. The visit may last up to 5 days. Participants will have:
* Medical history * Physical exam * Musculoskeletal exam * Questions about overall health and quality of life, disease activity, functional status, and cognitive ability.
Participants may also have:
* Pictures taken of their skin, joints, or spine * Blood, urine, and stool tests * Scans or X-rays of joints with arthritis * Chest X-ray * Heart tests * Skin biopsy. The skin will be numbed. The top layers of a small area will be scraped off.
Participants who have a joint aspiration may provide a fluid sample. The joint will be prepared, then fluid is removed by needle. A corticosteroid may be injected.
Participants who have a bone marrow biopsy may provide sample cells.
Participants may be seen by NIH specialists.
Members of the participant s family and healthy volunteers may give blood or saliva samples for genetic testing.
Participants may repeat some study tests every 6 months.
Patients with signs and symptoms of sJIA will be classified as outlined in Diagnosis/Classification Criteria.
Patients less than 16 years of age will be considered to have sJIA if they meet the ILAR criteria for sJIA.
Patients 16 years of age and older will be considered to have sJIA if they have previously met ILAR criteria for sJIA.
Patients with signs and symptoms of AOSD will be classified as outlined in Yamaguchi Criteria for diagnosing Adult-Onset Still's Disease.
In adults, inability, or the lack of capacity to provide informed consent. In the case of minors, unavailability of a parent or guardian.
Presence of any medical condition that would, in the opinion of the investigators, confuse the interpretation of the study.
Unavailability, or inability to adhere with the schedule for follow-up visits
Patients with systemic juvenile idiopathic arthritis (sJIA), adult-onset Still's disease (AOSD) and related inflammatory conditions.
Cohort
Prospective
Not listed
Genetic sequencing of patients
sequencing aims to identify variants to help stratify sJIA, Still's and inflammatory disease patients
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