The goal of this observational prospective cohort study is to learn about the natural course of central and mixed sleep apneas that develop after maxillomandibular advancement (MMA) surgery for obstructive sleep apnea (OSA) in adult patients.
The main question it aims to answer is:
Do central and mixed apneas resolve, partially resolve, or persist in the long term after MMA?
Participants will:
Undergo a first postoperative polysomnography (PSG) at 3-6 months after MMA (part of standard care).
Be invited into the study if central/mixed apneas are detected (CMAI% \>25%). Undergo a second PSG at least 12 months after MMA (extra study procedure)
Adults aged 18 years or older;
Mild to severe OSA as determined by a polysomnography (PSG) preoperatively;
Completion of MMA for OSA treatment;
Subjects with preoperative and postoperative PSG;
Patients who underwent other adjunctive procedures at the time of MMA (e.g., multi-piece Le Fort osteotomy, TMJ reconstruction);
Previous history of orthognathic surgery;
Cleft palate and syndromic patients.
Obstructive sleep apnea (OSA) patients who are present with maxillomandibular advancement (MMA) treatment-related central and mixed apneas.
Cohort
Prospective
Not listed
Apnea-hypopnea index (AHI)
Central apnea index (CAI)
Mixed apnea index (MAI)
The percentage of central and mixed apneas of AHI (CMAI%)
Lowest oxyhemoglobin saturation (LSAT)
Oxygen desaturation index (ODI)
Click on the lead sponsor to view all of their trials.
This trial is not recruiting at the moment. You can still explore other options:
