Background:
Lipodystrophy is a health problem in which the body does not have enough fat tissue. People with lipodystrophy may not make enough of the hormone leptin. Leptin regulates hunger. Low leptin levels trigger hunger. People with lipodystrophy can have many health problems. They may take a drug (metreleptin) that mimics leptin. Little is known about how taking metreleptin may affect a pregnancy. Metreleptin may be helpful or harmful to pregnant women. It may also affect the health of the child who is born.
Objective:
This natural history study will collect data about the effects of taking metreleptin while pregnant.
Eligibility:
Women aged 18 years or older with lipodystrophy who have been pregnant. Women who did and who did not take metreleptin during their pregnancies are needed. Children of women with lipodystrophy who took this drug during pregnancy are also needed.
Design:
Participants will have 1 study visit. This visit may be by phone, by telehealth, or in-person.
Participants will answer questions about their pregnancies.
They will discuss any health problems they had.
They will be asked about any medicines they took before and during their pregnancies.
They will be asked about the health of their children.
Participants medical records will be reviewed.
Participants may need to provide a blood sample. They may also be asked to provide a sample of breastmilk.
Participants children may also be asked to provide a blood sample....
Female, aged >= 18 years
Clinical diagnosis of non-HIV associated generalized or partial lipodystrophy
History of one or more pregnancies
Males or females aged >=1 month
Inability of subject or guardian to understand or the unwillingness to sign a written informed consent document (except as noted below with *)
Pregnancy.
Subjects who otherwise meet inclusion/exclusion criteria but who are not reachable to obtain informed consent may be included under a waiver of consent.
Women who were pregnant while taking metreleptin and their off-spring will be evaluated.
Case-only
Cross-sectional
Not listed
type and frequency of pregnancy complications
We will quantify a set of pregnancy and offspring outcomes and complications.
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