Participants recruited for this study will be breast cancer or gynecological cancer patients who agree to participate in an exercise study examining the effects of chemotherapy on muscle mitochondrial oxidative capacity, a measure of skeletal muscle health. Participants will ride a stationary bicycle and the quadriceps muscle will be non-invasively evaluated.
Patients diagnosed with breast cancer or gynecological cancer without distance metastasis
Able to perform exercise on a stationary cycle ergometer at moderate intensities for a maximum of 15 minutes
Hemoglobin values greater than 10 at baseline
ALT and AST values less than 2.5X the upper limit of normal by institutional standards
Metastatic breast or gynecological cancer
Clinically advanced cardiovascular disease
Clinically advanced pulmonary disease
Disease requiring continuous oxygen supplementation
This study focuses on breast cancer or gynecological cancer patients who will undergo a standard of care chemotherapy treatment as directed by their oncologist.
Cohort
Prospective
Not listed
Muscle mitochondrial oxidative capacity
Study staff will measure O2Hb, HHb, and TSI, via the NIRS PortaMon device during the on-off kinetics protocol.
Whole body oxygen uptake via indirect calorimetry
We also will measure ventilatory whole-body components including O2 and CO2 via the Parvomedics metabolic cart.
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University of South Carolina
Lead sponsor
Furman University
Collaborator
Prisma Health-Upstate
Collaborator
