About this trial
The study seeks to investigate the neurological effects caused by Covid-19 in children and adolescents in the 6-16 age group. To do this, neuropsychological scales, an EEG and an MRI were used.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age between 6 years and 16 years and 11 months
Symptomatology compatible with long neurological COVID, specifically: persistence or appearance of new neurological signs/symptoms (e.g. fatigue, headache, sleep disturbance, cognitive dysfunction, memory difficulties, emotional or mood disorders, vertigo cognitive dysfunction, memory difficulties, emotional or mood disorders, dizziness, dysautonomia, movement disorders movement disorders, ataxia, tremor, epilepsy, muscle weakness, myalgia, hyposmia, hypogeusia hearing loss or tinnitus and/or sensorimotor deficits such as hypoesthesia, dysesthesia) after three months after established SARS-CoV-2 infection, as well as persistence of these symptoms for at least two months, in the absence of a clear aetiology.
Signature of the appropriate Informed Consent by caregiver(s) and patient(s)
Disqualifiers
Poor knowledge of the Italian language or other limitation of verbal communication that compromises the subject's ability to perform neuropsychological tests
Need for sedation to perform brain MRI 7 Tesla
Neurological or neuropsychiatric disorder diagnosed prior to COVID-19 diagnosis
Caregiver's failure to sign consent
Trial design
Sequential
Treatments tested in this trial
Psychological tests, EEG, Magnetic Resonance
Diagnostic testPatients are administered some psychological tests, if they are positive they move on to the next stage, otherwise the patients leave the practice. If they are positive, EEG, MRI and other psychological tests are also administered.
Treatment groups
Trial outcomes
Primary outcomes
Changes in cognitive and neuropsychological functions in children and adolescents with Long COVID between T0 and T1.
Assessment of cognitive, neuropsychological and adaptive skills in children and adolescents with Long COVID by means of standardised tests (WISC-IV, CPT3, NEPSY II, BRIEF-2, Vineland Adaptive Behavior Scales). The tests measure attention, memory, executive functions, intellectual-adaptive functioning and quality of life.
Sponsors and contacts
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