Network Effects of Left M1 rTMS: A TMS-EEG Study
ConditionCortical Plasticity
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-60
SponsorAalborg University
About this trial
This study investigates the modification of connectivity patterns in response to one session of active repetitive transcranial magnetic stimulation (rTMS) applied to the primary motor cortex. Transcranial magnetic stimulation (TMS) will be applied to elicit electroencephalography (EEG) responses in healthy volunteers. TMS-evoked potentials (TEPs) will be recorded before and after the rTMS session and will serve as a reflection of cortical connectivity to TMS. Four cortical targets will be stimulated for TMS-EEG assessment: left primary motor cortex, right primary motor cortex, left premotor cortex, and right occipital cortex.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Healthy men and women
Speak and understand English
Disqualifiers
Drug addiction defined as the use of cannabis, opioids or other drugs
Previous neurologic, musculoskeletal or mental illnesses
Lack of ability to cooperate
History of chronic pain or current acute pain
Trial design
Design model
Single group
Treatments tested in this trial
rTMS
Other interventionRepetitive transcranial magnetic stimulation (rTMS) is applied to the primary motor cortex. The protocol consists of 15 minutes of 10Hz stimulation, 10 seconds on, 20 seconds off, at 90% RMT, for a total of 3000 pulses.
Treatment groups
20 Participants
are divided into 1 treatment groupGroup A: Active Comparator : Classical rTMS to M1Experimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Cortical connectivity
Global and local mean field amplitude
Time frame
Cortical connectivity changes will be investigated before and after rTMS (1 hour)Secondary outcomes
1
Cortical connectivity
TMS-evoked potentials
Time frame
Cortical excitability changes will be investigated before and after rTMS (1 hour)Sponsors and contacts
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Source ClinicalTrials.gov