About this trial
The goal of this observational study is to understand the effects of gut microbiota dysbiosis treatment in patients with inflammatory bowel disease (IBD) combined with depression. The main question it aims to answer is:
Does fecal microbiota transplantation (FMT) improve depression symptoms in IBD patients by altering GABA levels in the medial prefrontal cortex?
Participants already undergoing fecal microbiota transplantation (FMT) as part of their regular medical care for IBD and comorbid depression will undergo regular assessments of GABA levels, gut microbiota, and depression symptoms for the duration of the study.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
None
Disqualifiers
None
Trial population
The inflammatory bowel disease (IBD) combined with depression have increased psychological stress. Individuals with IBD often face prolonged physical discomfort and treatment challenges, which can lead to increased emotional burden and susceptibility to depression. IBD is a chronic condition requiring long-term management and treatment. These ongoing lifestyle changes and medical burdens may contribute to feelings of sadness and depression. In summary, depression is common among individuals with inflammatory bowel disease. It is important to monitor the mental health of patients during treatment and provide proactive psychological support and intervention when needed.
Trial design
Case-control
Cross-sectional
Treatments tested in this trial
Magnetic resonance imaging scanning
RadiationPerform brain diffusion imaging, magnetic resonance spectroscopy, and functional magnetic resonance imaging scans on all individuals
FMT Protocol
DrugTreatment of disease groups (UC and CD) using prepared fecal microbiota transplantation solution
Treatment groups
Trial outcomes
Primary outcomes
Magnetic resonance spectroscopy
Changes in GABA content in the prefrontal lobe of the brain
Magnetic resonance spectroscopy
Changes in alpha diversity and differential abundance of gut microbiota
Locations
Sponsors and contacts
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This trial is not recruiting at the moment. You can still explore other options: