Neural Control of Gait & Navigation in ADRD
ConditionAging
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65-89
SponsorUniversity of Florida
About this trial
Brain network segregation, or independent functioning, declines with age and is associated with slower walking speed. Here, the investigators will determine the extent to which brain vestibular network segregation can be altered with bilateral vestibular cortical transcranial direct current stimulation (tDCS) in older adults with subjective cognitive decline. Participants will be randomly assigned to an active or sham stimulation condition. They will receive three, 20-minute sessions of tDCS while they are walking and performing cognitive tasks. MRI of the brain will be acquired before and after these three sessions.
Eligibility criteria
Qualifiers
Community dwelling men and women 18-35 years old or 65-89 years old
Ability to walk unassisted for ten minutes
Willingness to undergo all testing procedures
English speaking Additional Inclusion Criteria for those with SCD
Disqualifiers
Significant medical event requiring hospitalization in the past 6 months that has the potential to contaminate data being collected (fracture, hospitalization etc.)
Severe visual impairment or corrected visual acuity less than 20/40, which would preclude completion of the assessments
Inability to undergo brain imaging due to claustrophobia or implants such as pacemakers, heart valves, brain aneurysm clips, orthodontics, non-removable body jewelry, or shrapnel containing ferromagnetic metal
tDCS ineligibility for Aim 3 (history of epilepsy, medications that alter cortical excitability, etc.)
Trial design
Treatments tested in this trial
- Transcranial direct current stimulation
Treatment groups
60 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of Florida
Lead sponsor
National Institute on Aging (NIA)
Collaborator
Source ClinicalTrials.gov