Health TrialsbyHealthPanel

Neural Correlates of Stress and Perceived Control in Adolescent Depression

ConditionMajor Depressive Disorder
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age14-18
SponsorMclean Hospital

About this trial

Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived control disruptions in MDD remain poorly understood. Using functional magnetic resonance imaging with a novel "value of control task" in conjunction with a prospective design, this study will provide a comprehensive understanding of stress and perceived control related mechanisms in female adolescents with MDD and will examine stress-induced disruptions in perceived control as a predictor of "real world" expressions of maladaptive coping and anhedonia.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Inclusion Criteria: All Participants

Females of all ethnic origins See Section: Inclusion of Women and Minorities);

Ages 14-18 (See Section: Inclusion of Children);

Written informed assent/consent from adolescent and parent/guardian (if under age 18);

Disqualifiers

Exclusion Criteria: All Participants

History of head trauma with loss of consciousness;

History of seizure disorder;

Serious or unstable medical illness including cardiovascular, hepatic, renal, respiratory, endocrine, neurologic or hematologic disease;

Trial design

Design model

Single group

Treatments tested in this trial

  • Computer Task Manipulation

    Behavioral

    Participants will complete computer tasks.

Treatment groups

80 Participants
are divided into 1 treatment group
Group A: Computer Task ManipulationExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Blood-Oxygen-Level-Dependent Imaging (BOLD) activation of the ventral striatum and ventral medial prefrontal cortex

BOLD activation of frontostriatal regions in response to computer tasks performed during the fMRI Brian scan

Time frame
1.5 hour long scan during session 2

Secondary outcomes

1

Cortisol Rating

Saliva rating to be collected throughout the fMRI brain scan

Time frame
collected as part of 1.5 hour long scan during session 2
2

Mood Rating

Self-reported mood rating to be collected throughout the fMRI brain scan

Time frame
collected as part of 1.5 hour long scan during session 2
3

Stress Reactivity Score

Stress Reactivity Survey Item collected via smart-phone delivered ecological momentary assessment

Time frame
Longitudinal, three time points (baseline, 3-month follow-up, 6-month follow-up)
4

Stress Reactive Rumination Score

Stress Reactive Rumination Scale collected via smart-phone delivered ecological momentary assessment

Time frame
Longitudinal, three time points (baseline, 3-month follow-up, 6-month follow-up)

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Mclean Hospital

Lead sponsor

Source ClinicalTrials.gov
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