About this trial
Deciding what to do when for how long - self-organizing one's behaviour - is an important feature of daily life. Emotions arise providing short-cuts for the computational complexities. Yet, one still knows relatively little about the underlying cognitive and neural mechanisms. EMOBB will establish the computational, cognitive and neural underpinnings of the rich interplay between emotions and self-organized behaviour in naturalistic environments. Previous work has almost exclusively relied on tasks structured into experimenter determined trials - thus how people self-organized behaviour could not be measured. To overcome this, EMOBB will combine novel naturalistic tasks in which people have freedom what to do when for how long with subjective and objective measurements of emotions. This will be made possible through a computational modelling approach that allows dissecting and quantifying even complex behaviour-emotion interactions.
Specifically, EMOBB will use three cognitive tasks of emotion-behaviour interplay that participants will do while undergoing functional magnetic resonance brain imaging and monitoring of their facial expressions with an MRI-compatible camera.
The primary hypothesis of EMOBB is that both unique and shared neural networks will underpin the interplay between emotions and behaviour across our cognitive tasks.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
18-45 years old,
fluent French speakers,
healthy,
without a beard at the time of testing,
Disqualifiers
neurological, psychiatric disorders, or severe chronic disorders (diabetes, cardiac, kidney, lung, liver disorders, inflammatory disorders)
pregnancy or breast-feeding
under guardianship, currently admitted to a psychiatric hospital other than for research purposes)
not wanting to be informed of abnormalities detected during MRI scan,
Trial design
Parallel
Treatments tested in this trial
Functional Magnetic Resonance Imaging (fMRI)
Other interventionParticipants will perform a cognitive task (responses through button presses) while we measure brain activity with functional magnetic resonance imaging (fMRI) and record their facial expressions.
Treatment groups
Trial outcomes
Primary outcomes
Brain activity in regions of interest
Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to baseline across tasks across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
Secondary outcomes
Brain activity during task 1 (Self-organization under threat)
Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to rest in task 1 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
Brain activity during task 2 (Self-organization and learning)
Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) compared to rest in task 2 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
Brain activity during task 3 (Self-organization and social context)
Brain activity is captured as percentage change in blood-oxygen-level-dependent (BOLD) signal with FMRI compared to rest in task 3 across brain regions (ventromedial prefrontal cortex, vmPFC; dorsal anterior cingulate cortex, dACC).
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
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