Neural Mechanisms of Family-Focused Treatment for Youth Depression
ConditionChildhood Depression
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age7-12
SponsorBoston University Charles River Campus
About this trial
The goal of this interventional study is to compare the baseline neural mechanisms and parenting in depressed and non-depressed children and to examine baseline neural mechanisms and parenting as predictors of Family-Focused Treatment for Childhood-Depression (FFT-CD) outcomes. The main questions it aims to answer are:
* What are differences between depressed and non-depressed participants on baseline neural and parenting indicators? * Do baseline neural and parenting indicators predict response to FFT-CD? * Does change in parenting and neural functioning mediate change in depression from baseline to follow-up?
Participants will:
* complete baseline clinical measures * complete neuroimaging tasks via Functional Magnetic Resonance Imaging (fMR) * undergo a 12-session course of FFT-CD * complete follow up evaluations and neuroimaging
Eligibility criteria
Qualifiers
Have a current DSM-5 diagnosis of MDD, Persistent DD, or DDNOS (based on K-SADS-PL) OR not meet criteria for any DSM-5 mental health diagnosis (based on K-SADS-PL)
Be ages 7-12
Be living with a parent(s) or guardian willing to participate
Be able and willing to provide informed consent/assent
Disqualifiers
Thought or other disturbance in the child that would interfere with the ability to participate in treatment or assessments (e.g., psychotic disorder, autism spectrum disorder, OCD, active substance abuse/dependence, intellectual disability, as assessed on KSADS-PL)
Severe conduct disorders in the child that threaten the home stability (e.g. juvenile justice or children's protective service involvement as assessed on KSADS-PL) due to the potential impact on retention
Youth or primary caregivers do not speak English
Either parent or child has contraindications for neuroimaging (e.g., claustrophobia, metal implants, braces, electronically, magnetically, or mechanically activated devices such as cochlear implants)
Trial design
Treatments tested in this trial
- Family-Focused Treatment for Childhood-Depression (FFT-CD)
Treatment groups
80 Participants
are divided into 1 treatment groupSponsors and collaborators
Boston University Charles River Campus
Lead sponsor
Massachusetts Institute of Technology
Collaborator
Source ClinicalTrials.gov