Neural Mechanisms of Music Intervention Chronic Arm Hemiparesis Following Stroke: A Single Case Series EEG Study
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-110
SponsorAnglia Ruskin University
About this trial
The aims of the study are to recruit five participants with stroke upper limb hemiparesis and determine the effects on neural reorganisation of a three-week music intervention using electroencephalogram measures.
Secondly, the researchers will measure for changes in arm function before and after the three-week music intervention.
This is a single-arm pre-/post experiment
Primary research questions:
What are the neuroplastic changes induced by Therapeutic Instrumental Music Performance (TIMP)?
Secondary research questions What are the functional changes in hemiparetic arm and hand induced by TIMP?
Participants will be recruited once they have completed their statutory community stroke rehabilitation.
They will receive 15 X music therapy sessions in their home over three-weeks. Exercises will be delivered by trained clinicians, including music therapists and stroke rehabilitations specialists.
Exercises will be facilitated for full range of arm movement, using a range of percussion instruments on stands and handheld, and iPad with touchscreen instruments, which include keyboards and string instruments that can be played using pinch-grip, holding a stylus/plectrum.
Pre-/post intervention period EEG recordings will made. Stroke Specific Quality of Life (SSQoL), Action Research Arm Test and nine-hole-peg-test data will be collected from participants in their homes at weeks: 1, 4, 7 and 10.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Aged 18+
Ischemic stroke
Three weeks to 60 months post-stroke
12 to 49/57 Action Research Arm Test (ARAT) score *
Disqualifiers
Hemorrhagic stroke
No movement in arm
Unable to move thumb and one finger. Loss of sensation and proprioceptive impairment will not lead to exclusion.
Unable to consent to participate
Trial design
Design model
Single group
Treatments tested in this trial
Therapeutic Instrumental Music Performance
BehavioralExercises using musical instruments to improve hemiparetic hand and arm function
Treatment groups
5 Participants
are divided into 1 treatment groupGroup A: Music interventionExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Electroencephalogram (EEG): Power in EEG Alpha and Beta frequency bands
Power in EEG Alpha and Beta frequency bands (event-related synchronization and de-synchronization) during simple motor tasks
Time frame
baseline: pre-intervention, immediately after the interventionSecondary outcomes
1
Electroencephalogram (EEG): Amplitude of P3 event-related potential
The Amplitude of the P3 wave of the event-related potential, elicited during a working memory task
Time frame
baseline: pre-intervention, immediately after the intervention2
Electroencephalogram (EEG): Frontal Alpha Asymmetry
Magnitude of the Frontal Alpha Asymmetry during a resting-state EEG
Time frame
baseline: pre-intervention, immediately after the intervention3
Action Research Arm Test (ARAT)
A 19-item measure that is divided into: grasp, grip, pinch and gross movement. Maximum score is 57, which would indicate best possible arm and hand function
Time frame
Baseline, pre-intervention (week 4), post-intervention (week 7), follow-up (week 10)4
Nine hole peg test
Assessment of finger dexterity. Picking up nine pegs from a dish one at a time and placing into nine holes, then removing one by one and placing back in the dish. Maximum time allowed for our study will be two-minutes. A healthy male would complete it approximately 19 seconds.
Time frame
Baseline (week 1), pre-intervention (week 4), post-intervention (week 7), Follow-up (week 10)Other outcomes
1
Stroke Specific Quality of Life Questionnaire
A questionnaire asking stroke survivors to rate the impact of their stroke on various. (score range 49 - 245, with higher score indicating better quality of life)aspects of their daily living
Time frame
Baseline (week 1), pre-intervention (week 4), post-intervention (week 7), follow-up (week 10)Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Anglia Ruskin University
Lead sponsor
Cambridgeshire Community Services NHS Trust
Collaborator
Source ClinicalTrials.gov