About this trial
Premature neonates are able to discriminate phonemes and voice from 28wGA at a time the neuronal network establish contact between the environment and the cortical neurones. In the present monocentric study the investigators will analyse the response of the cortical network in premature aged between 25 and 36 wGA in response to auditory stimuli using High Resolution Electroencephalography and High Density Near Infrared Spectroscopy.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
full term neonates between 25 and 36 weeks gestational age
Disqualifiers
Neonates outside the age range
Trial design
Parallel
Treatments tested in this trial
EEG
Procedure/SurgeryResponse of the cortical network in premature aged between 25 and 36 wGA in response to auditory stimuli using High Resolution Electroencephalography will be performed
NIRS
Procedure/SurgeryResponse of the cortical network in premature aged between 25 and 36 wGA in response to auditory stimuli using High Density Near Infrared Spectroscopy will be performed
Treatment groups
Trial outcomes
Primary outcomes
measure at which age the ability to discriminate time features occurs in premature neonates with Matlab Friedtrip toolbox
measure at which age the ability to discriminate time features occurs in premature neonates. For the analysis of discrimination, the investigators will use cluster analysis as implemented in the Matlab Friedtrip toolbox.
Secondary outcomes
variation of the ability to discriminate time features between the IVH and normal preterm groups with BESA statistical tools
variation of the ability to discriminate time features between the IVH and normal preterm groups. For the analysis of time-frequency responses, the investigators will use cluster randomization procedures as implemented in the BESA statistical tools.
Sponsors and contacts
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