Neural Signatures of Processing the Temporal Features of Auditory Events: From Preterm Infancy to Adulthood

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age0-1
SponsorCentre Hospitalier Universitaire, Amiens

About this trial

Premature neonates are able to discriminate phonemes and voice from 28wGA at a time the neuronal network establish contact between the environment and the cortical neurones. In the present monocentric study the investigators will analyse the response of the cortical network in premature aged between 25 and 36 wGA in response to auditory stimuli using High Resolution Electroencephalography and High Density Near Infrared Spectroscopy.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

full term neonates between 25 and 36 weeks gestational age

Disqualifiers

Neonates outside the age range

Trial design

Design model

Parallel

Treatments tested in this trial

  • EEG

    Procedure/Surgery

    Response of the cortical network in premature aged between 25 and 36 wGA in response to auditory stimuli using High Resolution Electroencephalography will be performed

  • NIRS

    Procedure/Surgery

    Response of the cortical network in premature aged between 25 and 36 wGA in response to auditory stimuli using High Density Near Infrared Spectroscopy will be performed

Treatment groups

240 Participants
are divided into 2 treatment groups
Group A: normal 25-36 gestational week preterm infantActive comparator 2 interventions
Group B: 25-36 gestational week preterm infant with IVHExperimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

measure at which age the ability to discriminate time features occurs in premature neonates with Matlab Friedtrip toolbox

measure at which age the ability to discriminate time features occurs in premature neonates. For the analysis of discrimination, the investigators will use cluster analysis as implemented in the Matlab Friedtrip toolbox.

Time frame
at day 0

Secondary outcomes

1

variation of the ability to discriminate time features between the IVH and normal preterm groups with BESA statistical tools

variation of the ability to discriminate time features between the IVH and normal preterm groups. For the analysis of time-frequency responses, the investigators will use cluster randomization procedures as implemented in the BESA statistical tools.

Time frame
at day 0

Other outcomes

Sponsors and contacts

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