About this trial
Linguistic irregularities in number naming systems, such as the inversion of number words, affect the processing of Arabic numerals. Recently, it has been claimed that there is even a syntactic representation of number words. participant investigate the neurofunctional correlates of the syntactic processing of number words by examining different levels of place-value processing in a study with two complementary successive phases (Group 1 and Group 2) in healthy adults. In the first phase with Group 1, participant evaluate the unit-decade compatibility effect (UDCE) in two-digit magnitude comparisons. In the second phase with Group 2, participant investigate the carry-over effect in two-digit addition problems.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Subject aged 18 to 45 years;
Female or male;
Right-handed preference;
Subject, or legal representative, who has given consent to participate;
Disqualifiers
Not corresponding to the targeted age range;
Subject with contraindications to an MRI examination (pacemaker or neurosensory stimulator or implantable defibrillator, cochlear implants, ferromagnetic foreign bodies in the eyes or brain near neural structures, metal prostheses, patient agitation: non-cooperative or agitated patients, minors, claustrophobic subjects, pregnant women, ventriculoperitoneal neurosurgical shunt valves, dental braces);
Subject with chronic alcohol or drug use;
Abuse or dependence on substances (except nicotine) or toxic substances for more than 5 years or having led to comas (overdoses);
Trial population
In the experimental phase, 42 adult volunteers (a total of 84), selected according to strict criteria, will undergo an MRI scan, each comprising: - anatomical acquisition, - functional acquisition of activation during a number processing task (Phase 1: two-digit number magnitude comparison; Phase 2: multi-digit mental arithmetic).
Trial design
Case-only
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
Neurofunctional variables (fMRI)
the comparison of pairs of incompatible numbers compared to pairs of compatible numbers during the comparison of numbers.
Structural variables (structural MRI)
the comparison of problems of addition with and without restraint during mental arithmetic.
Behavioral variables,
we compare performance to the post-imaging reading test
structural variables
recording of morphological and brain morphometric characteristics.
Secondary outcomes
Handedness score
Measuring the lateralization of the hand will allow to recognize, based on the proposed activities, the dominant hand.
Demographics questionnaire
this questionnaire which will allow the collection of all the precise information about the participant
Sponsors and contacts
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