Neurocognitive Mechanisms of Sentence Production Impairment in Aphasia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Maryland, College Park
About this trial
The proposed research is relevant to public health because stroke is a leading cause of long-term disability among older adults and communication impairments resulting from stroke have a significant negative impact on quality of life. By seeking to better understand post-stroke aphasia, this project lays the groundwork for development of new interventions, and aligns with NIDCD's priority areas 1 (understanding normal function), 2 (understanding diseases), and 3 (improving diagnosis, treatment, and prevention).
Eligibility criteria
This trial accepts healthy volunteersQualifiers
At least 18 years of age
Persons with acquired aphasia are defined as those with a language impairment following left hemisphere brain injury (most likely a stroke).
Neurotypical adults need to be either young (ages 18-30 years) or older (> 60 years)
Native (or primary) speakers of English
Disqualifiers
Prior neurological or psychiatric diagnoses or developmental disabilities before the onset of aphasia
do not speak English fluently
Trial design
Design model
Single group
Treatments tested in this trial
Language Condition
BehavioralThe intervention involves asking participants to speak and understand words and sentences with different linguistic manipulations such as morphological, semantic, phonological priming, predictability of the subject and object nouns associated with verbs, naming of verbs and nouns, production of sentences with past, future or present tense. Accuracy, response times and brain activity are the outcome measures.
Treatment groups
350 Participants
are divided into 1 treatment groupGroup A: Language conditionExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Accuracy
Response accuracy for each experimental condition will be measured
Time frame
through the completion of the study, an average of 1 year2
Response time
Response times for each experimental condition will be measured
Time frame
through the completion of the study, an average of 1 year3
Brain activity
Patterns of brain activity (using magnetoencephalography and MRI) will be measured for each experimental condition
Time frame
through the completion of the study, an average of 1 yearSponsors and contacts
Click on the lead sponsor to view all of their trials.
University of Maryland, College Park
Lead sponsor
McMaster University
Collaborator
Source ClinicalTrials.gov