About this trial
The purpose of this study is to understand brain function, how people make decisions when they interact with others, and how brain function and behavior relate to personality traits.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
English fluency
US residency
Owner of a desktop or laptop computer
Adult aged 18-100
Disqualifiers
Participants who have participated in an earlier version of the study
Inability to consent
Self-reported history of neurological disorder or brain damage
Self-endorsed history of psychosis or mania
Trial design
Parallel
Treatments tested in this trial
Social Learning Task Battery, Clinical Cohort
BehavioralIn the primary study task, participants engage in a modified iterative trust game. The task is completed in the fMRI scanner and takes about 35 minutes. Participant choices earn feedback in the form of monetary gains or losses. All participants are debriefed on the motivation behind the task at the end of their visit.
Social Learning Task Battery, Online Cohort
BehavioralIn the primary study task, participants engage in a modified iterative trust game. Participant choices earn feedback in the form of monetary gains or losses. All participants are debriefed on the motivation behind study task at the end of their visit.
Treatment groups
Trial outcomes
Primary outcomes
Participant-level Coaxing Score
Participant coaxing behavior will be measured during the primary social learning task. Coaxing will be operationalized as the difference in the participant's return rate between exchange and secrecy modes on trials in which the coplayer decides not to share. In exchange mode, the participant knows whether the coplayer chose to share or keep the monetary incentive before indicating whether they would return it. In secrecy mode, the participant must make the return decision before learning the coplayer's choice. The coaxing score is calculated as the exchange-mode return rate minus the secrecy-mode return rate. Scores range from -1 to 1, with positive values indicating greater strategic coaxing and 0 indicating no difference between modes.
Secondary outcomes
Mean Informant-rated Momentary Manipulativeness
Manipulativeness will be assessed using the study-specific Interpersonal Dynamics EMA Battery. The informant-rated manipulativeness scale contains 3 items, each rated from 1 ("strongly disagree") to 5 ("strongly agree"). At each assessment, responses to the 3 items will be averaged to produce a momentary manipulativeness score that ranges from 1 to 5. Higher scores indicate greater informant-rated manipulativeness.
Latent Mentalizing Factor
A latent mentalizing factor will be derived using CFA, with participants' scores on three social cognition tasks serving as indicators. The latent factor will be standardized to a mean of 0 and standard deviation of 1 in the study sample and therefore has no fixed theoretical minimum or maximum. Higher factor scores indicate greater mentalizing ability.
Interpersonal Stress
Interpersonal stress will be assessed using the marital- or partner-relationship and other-relationship life domains of the Stress and Adversity Inventory for Adults. At each follow-up, the frequency scores for stressors in these two domains will be averaged to produce an interpersonal stress score. The score ranges from a minimum of 0 stressors, with no limit on reported stressor maximums. Higher scores indicate more frequent exposure to interpersonal relationship stressors.
Sponsors and contacts
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University of Pittsburgh
Lead sponsor
University of Pittsburgh Medical Center
Collaborator
Emory University
Collaborator
National Institute of Mental Health (NIMH)
Collaborator
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