Neurocomputational Dynamics of Cooperation

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-100
SponsorUniversity of Pittsburgh

About this trial

The purpose of this study is to understand brain function, how people make decisions when they interact with others, and how brain function and behavior relate to personality traits.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

English fluency

US residency

Owner of a desktop or laptop computer

Adult aged 18-100

Disqualifiers

Participants who have participated in an earlier version of the study

Inability to consent

Self-reported history of neurological disorder or brain damage

Self-endorsed history of psychosis or mania

Trial design

Design model

Parallel

Treatments tested in this trial

  • Social Learning Task Battery, Clinical Cohort

    Behavioral

    In the primary study task, participants engage in a modified iterative trust game. The task is completed in the fMRI scanner and takes about 35 minutes. Participant choices earn feedback in the form of monetary gains or losses. All participants are debriefed on the motivation behind the task at the end of their visit.

  • Social Learning Task Battery, Online Cohort

    Behavioral

    In the primary study task, participants engage in a modified iterative trust game. Participant choices earn feedback in the form of monetary gains or losses. All participants are debriefed on the motivation behind study task at the end of their visit.

Treatment groups

1,612 Participants
are divided into 3 treatment groups
Group A: Online CohortExperimental treatment 1 intervention
Group B: Clinical CohortExperimental treatment 1 intervention
Group C: InformantsNo intervention 0 interventions

Trial outcomes

Primary outcomes

1

Participant-level Coaxing Score

Participant coaxing behavior will be measured during the primary social learning task. Coaxing will be operationalized as the difference in the participant's return rate between exchange and secrecy modes on trials in which the coplayer decides not to share. In exchange mode, the participant knows whether the coplayer chose to share or keep the monetary incentive before indicating whether they would return it. In secrecy mode, the participant must make the return decision before learning the coplayer's choice. The coaxing score is calculated as the exchange-mode return rate minus the secrecy-mode return rate. Scores range from -1 to 1, with positive values indicating greater strategic coaxing and 0 indicating no difference between modes.

Time frame
During behavioral task visit at study baseline (clinical cohort) or during single online study session (online cohort)

Secondary outcomes

1

Mean Informant-rated Momentary Manipulativeness

Manipulativeness will be assessed using the study-specific Interpersonal Dynamics EMA Battery. The informant-rated manipulativeness scale contains 3 items, each rated from 1 ("strongly disagree") to 5 ("strongly agree"). At each assessment, responses to the 3 items will be averaged to produce a momentary manipulativeness score that ranges from 1 to 5. Higher scores indicate greater informant-rated manipulativeness.

Time frame
Post-baseline 21-day EMA period within year 1 of the study
2

Latent Mentalizing Factor

A latent mentalizing factor will be derived using CFA, with participants' scores on three social cognition tasks serving as indicators. The latent factor will be standardized to a mean of 0 and standard deviation of 1 in the study sample and therefore has no fixed theoretical minimum or maximum. Higher factor scores indicate greater mentalizing ability.

Time frame
Baseline
3

Interpersonal Stress

Interpersonal stress will be assessed using the marital- or partner-relationship and other-relationship life domains of the Stress and Adversity Inventory for Adults. At each follow-up, the frequency scores for stressors in these two domains will be averaged to produce an interpersonal stress score. The score ranges from a minimum of 0 stressors, with no limit on reported stressor maximums. Higher scores indicate more frequent exposure to interpersonal relationship stressors.

Time frame
At 12, 24, and 36 months after baseline

Other outcomes

Sponsors and contacts

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University of Pittsburgh

Lead sponsor

University of Pittsburgh Medical Center

Collaborator

Emory University

Collaborator

National Institute of Mental Health (NIMH)

Collaborator

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