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Neuromuscular Control and Motor Unit Behavior in Patients With Knee Osteoarthritis

ConditionKnee Osteoarthritis (Knee OA)
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age55-75
SponsorKaohsiung Veterans General Hospital.

About this trial

This study aims to examine the effects of moderate-intensity strength training, performed with or without an unloading knee orthosis (valgus-corrective or sham mode), on muscle function, motor unit behavior, and force modulation in patients with moderate knee osteoarthritis

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

1. Knee or lower extremity injury: Recent (within the past 6 months) history of severe injury, fracture, or surgery to the knee or lower extremity.

Trial design

Design model

Parallel

Treatments tested in this trial

  • the strengthening program

    Behavioral

    The isometric knee-extension strengthening program from session 1 to session 9 as follows: 1. Before the first training session each week, one-repetition maximum (1RM) will be measured to determine the training intensity for that week. 2. Training frequency: Three sessions per week on non-consecutive days, for a total of 3 weeks (9 sessions). 3. Training intensity: 60% of 1RM. The goal is to improve quadriceps strength and endurance while reducing joint loading. 4. Each session will consist of four sets: 30 repetitions in the first set and 15 repetitions in sets 2-4. 5. Rest intervals of 30 seconds will be provided between sets, during which the blood-flow-restriction device will remain in place.

Treatment groups

120 Participants
are divided into 3 treatment groups
Group A: controls groupSham comparator 1 intervention
Group B: Group A with the corrective knee orthosisExperimental treatment 1 intervention
Group C: Group B without the corrective knee orthosisPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

maximal voluntary isometric contraction (MVC)

Time frame
Baseline and 3 weeks
2

The Western Ontario and McMaster Universities Turkish (WOMAC) index

a self-administered questionnaire that assesses three aspects of a patient's health status -pain, stiffness, and physical function - in those with lower limb Osteoarthritis. WOMAC consists of 24 questions, with a total score ranging from 0 to 96 points. there are three subscales: pain (5 questions), stiffness (2 questions), and physical function (17 questions). a five-tier classification of symptomatic severity: minimal or no symptoms (≤24 score), mild (25-41 score), moderate (42-69 score), severe (70-86 score), and extreme (≥87 score).

Time frame
baseline, 3 weeks
3

The Knee Injury and Osteoarthritis Outcome Score (KOOS)

a knee-specific instrument, developed to assess the patients' opinion about their knee and associated problems. Knee Injury and Osteoarthritis Outcome Score (KOOS) has five subscales: pain (9 questions), symptoms (7 questions), activities of daily living (17 questions), sport/recreation (5 questions), knee-related quality of life (4 questions). The total score of each question (0-4 points) is converted into a score of 0-100, where 100 points represents the best knee health and 0 points represents the worst.

Time frame
Baseline and 3 weeks
4

Motor Unit Recruitment (amplitude relative to recruitment threshold)

surface EMG decomposition

Time frame
Baseline and 3 weeks

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Kaohsiung Veterans General Hospital.

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: