Neuropsychological Patterns of Suicide Ideators and Suicide Attempters

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Bern

About this trial

The present study consists of 3 projects in total and aims to investigate the (neuro-) psychological patterns from suicidal ideation to suicidal behavior as well as the effects and feasibility of ASSIP Home Treatment.

The overall aim of project 1 is to determine (neuro-) psychological differences between suicide attempters, suicide ideators, a clinical control group, and healthy controls. Study participants in project 1 will participate in a one-time (neuro-) psychological assessment.

Project 1 of this study is an observational cross-sectional study with four groups that will be conducted at the University Hospital of Psychiatry and Psychotherapy Bern (Switzerland): Patients with at least one suicide attempt in their past (SUAT), patients with suicidal ideation (SUID), patients from the same clinical cohort, without neither suicidal behavior or ideation (CLIN) and the healthy group (HLTH). The cohorts to be examined (SUAT \& SUID) will be compared to the two control groups (CLIN \& HLTH). Only people who have signed the informed consent and meet the eligibility criteria can participate in this study.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Informed consent as documented by signature

Age ≥ 18 years

Disqualifiers

Serious cognitive impairment

Any current psychotic disorder

Any current medication, which substantially impairs the attention span, reaction rate or any other relevant cognitive functions

Inability to follow the procedures of the study (e.g., insufficient mastery of the German language, previous enrolment into the current study)

Trial population

This quantitative cross-sectional study with four groups will be conducted at the University Hospital of Psychiatry and Psychotherapy, Bern. Patients with at least one suicide attempt in their past (SUAT), patients with suicidal ideation (SUID), patients from the same clinical cohort without neither suicidal behavior or ideation (CLIN), and the healthy group (HLTH). The cohorts to be examined (SUAT \& SUID) will be compared to two control groups (CLIN \& HLTH).

Trial design

Design model

Case-control

Time perspective

Cross-sectional

Treatments tested in this trial

  • (Neuro-)psychological assessment

    Other intervention

    The measurement, which takes place 1 week after the informed consent, aims to determine the distinct (neuro-) psychological patterns of suicidal behavior versus suicidal ideation, in comparison to two control groups.

Treatment groups

180 Participants
are divided into 4 treatment groups
Group A: Suicide attempters1 intervention
Group B: Suicide ideators1 intervention
Group C: Clinical control group1 intervention
Group D: Healthy controls1 intervention

Trial outcomes

Primary outcomes

1

Differences in Inhibitory Control

The Go/No-Go task is a cognitive task to assess an individual's ability to inhibit a prepotent response. It is used to measure impulse control and response inhibition. The task requires participants to respond ("Go" response) to one type of stimulus and to withhold or inhibit their response ("No-Go" response) to another type of stimulus. The Go/No-Go task yields measures such as reaction time, accuracy, and the ability to inhibit responses. Reaction times can vary widely, and accuracy is often expressed as a percentage of correct responses. Lower reaction times and higher accuracy in withholding responses (No-Go trials) indicate better inhibitory control and cognitive performance.

Time frame
The assessment takes place 1 day to 1 week after informed consent.

Secondary outcomes

1

Selective Attention and Interference Control

The Stroop task is a cognitive psychology test that evaluates an individual's ability to selectively attend to information while inhibiting interference from irrelevant stimuli. The Stroop task measures the time taken to complete tasks and the accuracy of responses. The primary measures are the time taken to complete the task and the number of errors. Lower completion times and fewer errors indicate better cognitive control and attentional focus. Lower scores (faster completion times and fewer errors) are associated with better outcomes, reflecting more efficient cognitive processing and interference control. Higher scores, if used to quantify errors or time taken, are associated with a worse outcome, indicating greater interference and potentially reduced cognitive control.

Time frame
The assessment takes place 1 day to 1 week after informed consent.

Other outcomes

1

Mental abilities like attention, working memory and visuomotor speed as well as mental flexibility

The Trail Making Test (TMT-A/B) is a neuropsychological test that assesses visual attention and task-switching abilities. It consists of two parts (Part A and Part B) and measures the time taken to complete each part. The score is typically represented as the time (in seconds) taken to complete the task. Lower scores (faster completion times) are generally considered better outcomes, indicating more efficient visual attention, processing speed, and cognitive flexibility. Higher scores (longer completion times) may suggest difficulties in these cognitive domains and are typically associated with worse outcomes.

Time frame
The assessment takes place 1 day to 1 week after informed consent.
2

Attention and Concentration Abilities

The D2 Test of Attention and Concentration is a neuropsychological test used to assess selective and sustained attention. It is employed to evaluate an individual's visual scanning, concentration, and information processing speed. The D2 Test involves scoring based on the number of correctly marked items minus the number of errors. The scoring method considers both the quantity and accuracy of responses. The goal is to mark as many target items as possible within a specified time limit while avoiding errors. A higher score is considered a better outcome, indicating more correct responses and effective attention and concentration.

Time frame
The assessment takes place 1 day to 1 week after informed consent.
3

Sociodemographic data

The Sociodemographic Questionnaire (DEMO) is a 30-item questionnaire that was developed to collect sociodemographic (e.g., gender, socioeconomic status, professional status, relationship satisfaction) and health-related data (e.g., medication, inpatient and outpatient treatment).

Time frame
The assessment takes place 1 day to 1 week after informed consent.
4

Diagnostic and Statistical Manual 5 (DSM-V) and International Classification of Diseases 10 (ICD-10) psychiatric disorders

The Mini-DIPS is a short, structured clinical interview for diagnosing mental disorders and is based on the DIPS-OA. The Mini-DIPS allows for a quick yet reliable diagnosis. It is applicable in adulthood and captures lifetime diagnoses, current and past diagnoses, based on the criteria of DSM-5 and ICD-10. The Mini-DIPS covers the mental disorders most commonly observed in clinical settings.

Time frame
The assessment takes place 1 day to 1 week after informed consent.

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