Neurorehabilitation Impact on Neurocognitive Impairments in Cerebellar Lesions

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
AgeNot listed
SponsorKlinik Bavaria

About this trial

Depending on their localization, cerebellar lesions cause various pronounced cognitive and/or affective dysfunctions, which are causally related to the involvement of cerebellar structures in neuronal networks for higher-order processing of cognitive and emotional items in the association areas of the cerebral cortex. For further investigation, event-related potential (ERP) analyses will be performed to record and visualize specific signals in the surface EEG, which should provide information about the course of treatment of neurorehabilitation with respect to a close correlation and thus predictive power to functional recovery that occurred as a result of cerebellar injury. With EEG parameters and clinical examination findings including neuropsychology, the functions for four thematically distributed domains (affective: prosody; cognitive: abstraction, linguistic and formal incongruence) will be recorded and evaluated over a four-week structured neurorehabilitation with an average therapy volume.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

active group: patients with a cerebrovascular lesion within the cerebellum

comparator group: patients with a cerebrovascular lesion supratentorial

Disqualifiers

any kind of history in neurological or psychiatric disorders

Trial design

Design model

Factorial

Treatments tested in this trial

  • Neurorehabilitation cerebellar cognitive disorder

    Other intervention

    Influence of neurorehabilitation treatment lines of physiotherapy and exercise therapy including scheduled occupational therapy to adapt and improve cognitive-affective disorders in cerebellar lesions.

Treatment groups

50 Participants
are divided into 2 treatment groups
Group A: Treatment in cerebellar lesioned patientExperimental treatment 1 intervention
Group B: Treatment in supratentorial lesioned patientActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Changes of attentional and executive functioning in active group.

Beneficial changes in attentional and executive function performance in ischemic cerebellar injury after structured neurorehabilitation modules. Measurements will be succeed by the Cerebellar Cognitive Affective/ Schmahmann Syndrome Scale (German version) with a maximum of 120 of 120 points, i.e. an increase of the test performance with higher point values along the neurorehabilitation procedure is considered as an indication of clinical improvement.

Time frame
26 weeks

Secondary outcomes

1

Extension of daily activities and life quality.

Growing action behavior (recorded by SF-36 scale) in everyday life, whereby an increase from low point values up to high point values (between a range of 0 points with very low quality of life as minimum, and up to 100 points as a maximum of quality of life) indicates a growing quality of life due to neurologic impromenet .

Time frame
52 weeks

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

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