Neutrophil to Lymphocyte Ratio and Postdural Headache
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age18+
SponsorIstinye University
About this trial
This study will aim to investigate whether systemic inflammatory markers-especially the neutrophil-to-lymphocyte ratio (NLR)-obtained from preoperative complete blood counts can predict the development of post-dural puncture headache (PDPH) in obstetric patients undergoing cesarean section under spinal anesthesia.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Women aged 18 years or older
Underwent elective or emergency cesarean section under spinal anesthesia
Had complete preoperative complete blood count (CBC) data available
No known hematological or inflammatory disease
Disqualifiers
Age under 18
Absence of preoperative complete blood count data
Presence of hematologic malignancy, active infection, autoimmune disease, or immunosuppressive therapy
Platelet count <150,000/mm³ or INR >1.5
Trial population
The study population consists of obstetric patients who underwent cesarean section under spinal anesthesia between January 2020 and December 2024 at a single tertiary center.
Trial design
Design model
Cohort
Time perspective
Retrospective
Treatments tested in this trial
PDPH
Other interventionObservational analysis of preoperative inflammatory markers (e.g., NLR, PLR, SIRI) in relation to PDPH development following spinal anesthesia.
Treatment groups
821 Participants
are divided into 2 treatment groupsGroup A: PDPH Group1 intervention
Group B: Non-PDPH Group1 intervention
Trial outcomes
Primary outcomes
1
Postdural Puncture Headache (PDPH) incidence
The occurrence of PDPH symptoms within 10 days following spinal anesthesia in obstetric patients, as documented in medical records.
Time frame
Within 10 days postoperativelySponsors and contacts
Click on the lead sponsor to view all of their trials.
Istinye University
Lead sponsor
Haseki Training and Research Hospital
Sponsor institution
Source ClinicalTrials.gov