NHLBI-Emory Advanced Cardiac CT Reconstruction
ConditionStructural Heart Disease
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-100
SponsorNational Heart, Lung, and Blood Institute (NHLBI)
About this trial
Background:
Doctors use computed tomography (CT) to get detailed pictures of the heart. CT uses x-rays to gather raw data. Computers assemble this data to make the images doctors look at. A new computer technique can make higher resolution images from the same CT scans. In this natural history study, researchers will take normal CT images of the heart. They will compare those images to super high-resolution (super high-res) images made with a super-computer.
Objective:
To improve the quality of heart CT scans by using new methods to create the images.
Eligibility:
People aged 18 years or older who need a CT scan for heart disease.
Design:
Participants will have a normal CT scan. A substance will be injected through a tube in their arm. They will lie on a table in a large, donut-shaped machine. An X-ray tube will move around their body, taking many pictures.
Researchers will use the normal CT scans to create super high-res images. They may do this at the NIH. They may also send the images to the company that made the CT scanner. Participants personal information will be removed before images are sent to the company. The personal information will be replaced by a code.
The super high-res images will be returned to the NIH.
Some information will be collected from participants medical records. Researchers will compare the normal scans to the super high-res images.
Participants' own doctors will also have a chance to see the super high-res images.
Participants' CT pictures will be stored and used for future NIH research.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Male or female, aged >= 18 years
Undergoing clinically-indicated contrast-enhanced time-resolved cardiac CT for structural heart disease.
Ability of subject to understand and the willingness to sign a written informed consent document.
Disqualifiers
Unable to complete contrast-enhanced cardiac CT acquisition for any reason
Unwilling to authorize future use of their imaging data for research
Trial population
Adults undergoing clinically-indicated contrast-enhanced time-resolved cardiac CT for suspected structural heart disease
Trial design
Design model
Case-only
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
1,000 Participants
are grouped into 1 trial groupGroup A: 1
Trial outcomes
Primary outcomes
1
The objective of this research protocol is to determine whether advanced mathematical image reconstructions create superior images compared with standard cardiac CT image reconstruction in patients with structural heart disease.
The primary endpoint is a semi-quantitative measure of superiority of advanced mathematical image reconstruction compared with standard cardiac CT image reconstruction for study-specific fine detail. Specifically, the endpoint is a Likert-like scale assessing visibility of small structures or fine detail.
Time frame
5 yearsSponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: