NLR and PLR in H. Pylori-Associated Gastritis
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAssiut University
About this trial
This cross-sectional study aims to evaluate the role of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as inflammatory markers in patients with Helicobacter pylori-associated gastritis at Assiut University Hospitals.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
- Age 18 years or older
Patients with dyspepsia
Patients undergoing endoscopy and biopsy for H. pylori testing
Willingness to provide informed consent
Disqualifiers
- Hematological diseases
Active infection other than H. pylori
Chronic inflammatory or autoimmune diseases
Malignancy
Trial population
Adult patients with dyspepsia undergoing endoscopy and biopsy for H. pylori testing at Assiut University Hospitals.
Trial design
Design model
Case-only
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Neutrophil-to-lymphocyte ratio (NLR) in H. pylori-associated gastritis
Neutrophil-to-lymphocyte ratio calculated from complete blood count in patients with confirmed H. pylori-associated gastritis compared with patients without H. pylori infection.
Time frame
BaselineSecondary outcomes
1
Platelet-to-lymphocyte ratio (PLR)
Platelet-to-lymphocyte ratio calculated from complete blood count in patients with and without H. pylori infection.
Time frame
Baseline2
Diagnostic performance of NLR
Sensitivity, specificity, and optimal cutoff value of NLR for predicting H. pylori infection using receiver operating characteristic (ROC) curve analysis.
Time frame
Baseline3
Diagnostic performance of PLR
Sensitivity, specificity, and optimal cutoff value of PLR for predicting H. pylori infection using ROC curve analysis.
Time frame
Baseline4
Correlation of NLR and PLR with severity of gastritis
Correlation coefficient between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values and the severity grade of gastritis based on endoscopic and/or histopathological findings, using Spearman or Pearson correlation as appropriate.
Time frame
BaselineLocations
Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: