this study is to compare no-sedation versus daily interruption of sedation (DIS) in Chronic obstructive pulmonary disease (COPD) patients receiving mechanical ventilation upon the ventilator-free days.
Patients of both sex aged 18 years or older
The study will include 60 patients divided into 2 equal groups
Invasive mechanical ventilation
Patients with COPD patients (post-bronchodilator FEV1/FVC< 70, and under follow through the department outpatient clinic) exacerbation admitted to the ICU and required invasive mechanical ventilation were recruited.
renal or hepatic impairment
proven or suspected psychiatric or neurological impairment
pregnancy
The study will include 60 patients divided into 2 equal groups
Case-control
Prospective
daily Interruption of Sedation
BehavioralThe patients will be managed by DIS. Richmond agitation and sedation score (RASS) will be used for monitoring the depth of sedation
Ventilator-free days
Ventilator-free days (Number of days from day-1 to day-28) on which the patient did not need assistance to his breathe.
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