The prevalence of aortic valve disease is increasing, with these valvulopathies present in half of individuals over the age of 65.
Oberbach A. et al (1) demonstrated the presence of microbiota in 52% of cases of explanted aortic valves. One current hypothesis is the role of this microbiota in the pathophysiology of these degenerative valve diseases. This microbiota is probably not completely eradicated after resection of the native valve and implantation of a conventional prosthesis; it is even left in place during percutaneous aortic valve implantation, during which the prosthesis is deployed within the native valve. It could therefore also play a role in the occurrence of postoperative complications and the degeneration or thrombosis of a bioprosthesis.
Furthermore, recent clinical and epidemiological studies have shown a link between oral infections and cardiovascular diseases. As recommended by the HAS, these patients require multidisciplinary care, involving cardiologists, cardiac surgeons and general practitioners, as well as careful oral and dental care and monitoring provided by specialists in oral pathologies and oral care. The accumulation of bacterial plaque on the surface of the tooth and certain oral bacteria causes the development of periodontal pockets which are characteristic of periodontitis. Bacteria, microbial products and inflammatory mediators produced locally can then enter the bloodstream and affect distant organs such as the cardiovascular system. The recommendations of the European Society of Cardiology are therefore to carry out regular oral and dental consultations to prevent the risk of infection. Therefore, within the Toulouse University Hospital, a care network has been set up for patients with cardiovascular pathologies, in order to improve their access to dental care, screening and management of oral diseases. For the past year, patients hospitalized in the cardiology departments have been seen in consultation in the dental department of the Toulouse University Hospital.
Male or female patient.
Present an indication for cardiac surgery that requires explantation of the aortic valve.
Be able to receive information about the study process and understand the study participation information form.
State their non-opposition to participating in the study.
Patients infected with HIV
Age under 18
Under court supervision, guardianship, or curatorship
Patients with a history of infective endocarditis.
Single group
Take 1 ml of blood
Biological/VaccineTake 1 ml of blood
DNA sequencing
Biological/VaccineDNA sequencing
Valve collection (healthcare waste)
Procedure/SurgeryValve collection (healthcare waste)
Collection of serious post-operative complications
Other interventionCollection of serious post-operative complications
Occurrence of a serious postoperative complication
Number of ischemic or hemorrhagic strokes; re-intervention, infective endocarditis, aortic bioprosthesis degeneration, aortic bioprosthesis thrombosis, mortality, surgical site infection requiring repeat surgery
Determine the microbiological composition of saliva
Determine the components of the salivary microbiota
Determine the components of the microbiota of periodontal plaque
Determine the components of the microbiota of periodontal plaque
Oral health assessment
Oral health assessment using the oral health assessment questionnaire called "Oral Study" which asks questions about the use of a toothbrush, interdental brushes, the frequency of visits to the dentist, and the use of mouthwash.
Evaluation of hygiene and dietary habits
Assessment of dietary habits using a questionnaire on eating habits and the frequency of consumption of certain foods (bread, rusks, rice, pasta, vegetables, fruits, dairy products, fish, meat) with multiple choices between: Several times a day - Once a day - Several times a week - Once or twice a month - Never
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