Fetal brain MRI is an essential diagnostic tool to inform parents about the prognosis of abnormalities detected on routine ultrasound. Recent work has shown that brain MRI measurements at the antenatal stage are predictive of the child's postnatal development. However, this work remains limited to basic research, in part because of the lack of normative curves of brain tissue volume evolution from fetal MRI acquired in clinical routine. This project aims to fill this gap. For this purpose, the project will exploit fetal MRI scans acquired in 4 French hospitals (Marseille, Nice, Montpellier and Paris): MRI scans without abnormalities will be centralized for analysis, and families who have undergone these scans will be contacted to evaluate the development of their children after birth. Normative curves will be established by applying a set of treatments developed by the laboratory in Marseille collaborating in the project. Ultimately, these curves will help to clarify the diagnosis of fetuses by providing a quantitative characterization of the normality of brain measurements.
None
Child suffering from a commissural malformation (anomaly of the corpus callosum)
Child with a genetic syndrome and/or chromosomal abnormality and/or deleterious mutation
Child with syndromic extra-cerebral malformations (including cardiac malformations)
Child with intrauterine growth restriction reported in the obstetrical record
Homogeneous group of fetuses who received an MRI more than 3 years ago, with normal MRI and normal neurological development at 3 years (see inclusion criteria). Included individuals (at the fetal stage) will be evaluated at 3+ years post-birth.
Other
Retrospective
Questionnaire
Other interventionQuestionnaire about children development
Determine normative brain volume curves
Curves calculated from fetal brain MRIs in fetuses between 20 and 37 weeks of amenorrhea with normal postnatal neurological development
Statistically compare the normative curves obtained with standard articles in the literature.
Comparaison of Size effect, confidence intervals obtained with those reported in the reference articles
Sensitivity study: Possible influence of the scanner type on the estimated normative curves.
MRI scanner model
Click on the lead sponsor to view all of their trials.
