the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection (2) to assess the production of CO in patients following liver resection and correlate these findings to the rate of liver regeneration and liver function.
Patient plans to have partial liver resection for primary liver pathology or metastatic disease
Patient is able to comprehend and willing to sign the written consent form
Patients < 18 years
Patients identified as members of a vulnerable population, except women of child bearing potential with negative pregnancy test
Single group
carbon monoxide measurement via smokerlyzer
Other interventionparticipants in this study will provide breath samples for carbon monoxide measurements pre and post liver resection
correlation of carbon monoxide levels in exhaled breath with quantity and quality of liver regeneration
patients will be asked to donate exhaled breath into a smokerlyzer device
level of carbon monoxide in exhaled air of patients
patients will be asked to donate exhaled breath into a smokerlyzer device
quantity of liver regeneration, liver volume (ml)
CT liver volumetric studies
quality of hepatic regeneration, normalized liver function
serum protein, albumin, AST and ALT, alkaline phosphatase, and bilirubin level
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