Nutritional Effects in Cardiovascular Surgery
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age50-80
SponsorFu Jen Catholic University
About this trial
This study aims to investigate the distribution of gut microbiota-derived metabolites, and to evaluate whether postoperative nutritional intervention can modulate the gut-heart metabolic axis, thereby improving metabolic profiles and clinical outcomes.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Scheduled to undergo cardiovascular surgery
Completed preoperative clinical and imaging evaluations
Willing to provide informed consent
Willing to receive potential probiotic supplementation
Disqualifiers
Use of antibiotics, probiotics, or other treatments affecting gut microbiota within 4 weeks
History of major gastrointestinal disease
Trial design
Design model
Parallel
Treatments tested in this trial
probiotic supplementation intervention
Other interventionprobiotic supplementation will be administered, while participants continue undergoing standard postoperative care
Placebo supplementation intervention
Other interventionUndergo routine standard postoperative care with placebo intervention
Treatment groups
30 Participants
are divided into 2 treatment groupsGroup A: Probiotic groupExperimental treatment 1 intervention
Group B: Placebo groupPlacebo comparator 1 intervention
Trial outcomes
Primary outcomes
1
Trimethylamine-N-oxide
Gut microbiota-derived metabolites
Time frame
From enrollment to the end of intervention at 3 weeks2
Phenylacetylglutamine
Gut microbiota-derived metabolites
Time frame
From enrollment to the end of intervention at 3 weeks3
P-cresyl sulfate
Gut microbiota-derived metabolites
Time frame
From enrollment to the end of intervention at 3 weeks4
Indoxyl sulfate
Gut microbiota-derived metabolites
Time frame
From enrollment to the end of intervention at 3 weeksSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov