Observational Study About the Use of Perfusion Index to Use Vasopressor in Sepsis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAin Shams University
About this trial
In this thesis we will use the current state of knowledge that PI can provide a reliable information about the state of peripheral microcirculation during the state of sepsis and septic shock in ICU patients and that can interfere with the timing of starting vasopressor treatment in sepsis and septic shock
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
Pregnant females
Patients on vasopressor or positive inotropic drugs
Patients with hypothermia (defined as central temperature <35°C).
Patient with impairment of upper extremity circulation,(such as those who underwent radial artery harvesting for coronary artery bypass grafting or had suspected occlusion of the radial artery prior to surgery,)
Trial population
ICU patients with sepsis
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Vasoconstrictor Agents
Drugvasopressor agents will be started in patients with sepsis who will not improved using the resuscitation fluids
Treatment groups
40 Participants
are divided into 2 treatment groupsGroup A: vasopressor1 intervention
Group B: no vasopressor0 interventions
Trial outcomes
Primary outcomes
1
PI (perfusion index ) variable will be measured at the start of resuscitation and at the start of vasopressor therapy
PI will be measured at the start of resuscitation after volume resuscitation and before the use of vasopressor then will be measured 6 hours after resuscitation
Time frame
PI variable will be recorded at baseline( T0 )and after 5 minutes from starting of resuscitation (T5) and then 6 hours thereafter for 24 hoursSecondary outcomes
1
Mean arterial Blood pressure
mean arterial blood pressure in mmHg
Time frame
Baseline (T0 ) ,5 miutes after initial fluid resuscitation (T5) and 6 hours thereafter (T6) for 24 hours2
Heart rate (HR)
in beat per minute (bpm)
Time frame
Baseline (T0 ) ,5 miutes after initial fluid resuscitation (T5) and 6 hours thereafter (T6) for 24 hours3
The central venous-arterial blood carbon dioxide partial pressure difference (Pv-aCO2)
The central venous-arterial blood carbon dioxide partial pressure difference (Pv-aCO2) will be calculated as the difference between the partial pressures of central venous carbon dioxide (PcvCO2) and arterial carbon dioxide (PaCO2).
Time frame
Baseline (T0 ) ,5 minutes after initial fluid resuscitation (T5) and 6 hours thereafter (T6) for 24 hours4
arterial lactate concentration
Time frame
Baseline (T0 ) ,5 minutes after initial fluid resuscitation (T5) and 6 hours thereafter (T6) for 24 hoursSponsors and contacts
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Source ClinicalTrials.gov