To remove a brain tumor, patients usually receive radiation to lower the chance that the cancer will come back in the spot where the tumor was removed.
Age ≥ 18 years.
ECOG performance status ≤ 2.
Participants with a resected brain metastasis with gross total resection and pathologic confirmation of NSCLC or melanoma. Gross total resection must be confirmed based on a review of the operative report, pathology, and all post-operative images available at the time of enrollment.
Brain metastasis resection occurred ≤ 5 weeks ago.
History of known leptomeningeal involvement (radiographic or cytological).
Subjects that have previously received or are currently planned for whole brain radiotherapy.
Prior unacceptable toxicity on one or more of the agents comprising the planned study systemic therapy.
Cognitively impaired subjects with a major medical, neurologic or psychiatric condition who are judged as unable to fully comply with study therapy or assessments should not be enrolled.