Health TrialsbyHealthPanel

Obstructive Sleep Apnea Among Somali-Americans

ConditionObstructive Sleep Apnea
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorMayo Clinic

About this trial

The investigators seek to advance the understanding of obstructive sleep apnea as it relates to different ethnic origins as well as sex differences. The investigators will compare Somali patients with known obstructive sleep apnea (OSA) to individuals without OSA, and to individuals of other ethnic/racial origins to determine the risk factors (genetic and/or physiologic) associated with developing cardiovascular diseases. This will help the investigators to understand the unique sleep pathology of individuals of African descent.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Self-identify as Somali, African, Asian, and European descent.

Adult males and females who are older than 18 years of age.

Disqualifiers

Minors under 18 years or adults over 100 years

Positive pregnancy

Trial population

The study population are individuals who are of Somali descent compared to those of different racial/ethnic origins.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

600 Participants
are grouped into 2 trial groups
Group A: Somali Descent
Group B: Non-Somali Descent

Trial outcomes

Primary outcomes

1

To assess the prevalence of obstructive sleep apnea

Measure the apnea-hypopnea index (AHI) to determine burden of obstructive sleep apnea. Based on the AHI, sleep apnea will be diagnosed if the AHI is ≥5 events/hour.

Time frame
10 years
2

To determine the severity of obstructive sleep apnea

The severity of OSA is classified based on the AHI as follows: None/Minimal: AHI \< 5 per hour, Mild: AHI ≥ 5, but \< 15 per hour, Moderate: AHI ≥ 15, but \< 30 per hour, Severe: AHI ≥ 30 per hour.

Time frame
10 years

Secondary outcomes

1

24 hour mean arterial pressure

Ambulatory measure of blood pressure in mmHg

Time frame
10 years
2

Vascular endothelial function

Change in brachial artery diameter in response to hyperemia

Time frame
10 years
3

Insulin sensitivity

Oral glucose tolerance testing

Time frame
10 years
4

Body composition

Percentage body fat content

Time frame
10 years

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Mayo Clinic

Lead sponsor

Sleep Number Corporation

Collaborator

Source ClinicalTrials.gov
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