Off-line Adaptive Proton Therapy
ConditionOropharyngeal Carcinoma
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age16+
SponsorUniversity Medical Center Groningen
About this trial
This prospective in-silico study evaluates a novel Off-line Adaptive Proton Therapy (o-APT) workflow for patients with oropharyngeal cancer receiving proton therapy. The study assesses whether automated image analysis, treatment plan adaptation, and quality assurance can identify and prepare treatment plan modifications more efficiently than current clinical practice, without affecting patient care.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Oropharyngeal cancer patients
Planned for curatively intended proton therapy
Treated with definitive radiotherapy, chemoradiation, or bioradiation
Provided informed consent according to Standard Follow-up Program (SFP) for using data for research
Disqualifiers
None
Trial population
Patients with oropharyngeal cancer receiving curatively intended proton therapy at the University Medical Center Groningen (UMCG)
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Off-line Adaptive Proton Therapy (o-APT) Workflow Evaluation
Other interventionEvaluation of an off-line adaptive proton therapy workflow using routinely collected clinical data
Treatment groups
100 Participants
are divided into 1 treatment groupGroup A: Oropharyngeal Cancer Patients Receiving Proton Therapy1 intervention
Trial outcomes
Primary outcomes
1
Dose Adjustments Ready to Use Before the Next Fraction
Availability of adapted treatment plans before the next treatment fraction
Time frame
From the first to the last radiotherapy fraction, approximately 7 weeks.Secondary outcomes
1
Accuracy of early identification of the need for treatment plan adaptation
Accuracy of the o-APT workflow in identifying the need for treatment plan adaptation, with particular focus on positive predictive value and negative predictive value.
Time frame
From the first to the last radiotherapy fraction, approximately 7 weeks.Sponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: