Office-Based Superior Laryngeal Nerve Block for Treatment of Neurogenic Cough
ConditionCough
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Alabama at Birmingham
About this trial
The purpose of this study is to evaluate if office-based injection of a local anesthetic/steroid combination at the area of one superior laryngeal nerve can decrease cough frequency and alleviate symptoms of chronic cough in patients with neurogenic cough.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Age 18 years or older
Ability of patients to speak and understand English
Ability for patients to consent for themselves
Cough for 8 weeks or greater, with suspected sensory neuropathic etiology of the cough. Inclusion based on history of preceding upper respiratory infection or other symptoms suggestive of irritable larynx such as cough in response to temperature changes, odors, scents/perfumes, tickle, irritation in the throat/paralaryngeal region, or talking.
Disqualifiers
Age less than 18 years
Patients unable or unwilling to provide informed consent
Known etiology to cough other than sensory neuropathy (e.g., reflux disease, asthma, allergic rhinitis, chronic obstructive pulmonary disease)
Addition of new neuromodulators at the time of the injection. Patients who were already being treated with neuromodulators for their cough (e.g., gabapentin, amitriptyline) will not be excluded provided their dose remains constant.
Trial population
Patients presenting to UAB Department of Otolaryngology for the evaluation and treatment of chronic cough who would be undergoing superior laryngeal nerve block as part of their standard clinical care.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
superior laryngeal nerve block
DrugA unilateral injection of 2 cc of a 1:1 mixture of 0.25% bupivacaine and Kenalog-40 via a 27 gauge needle to the thyrohyoid space (front of neck, just above larynx/voice box) via a 27 gauge needle to the thyrohyoid space (front of neck, just above larynx/voice box) on the side which exhibited most discomfort/tenderness/cough on palpation. If neither side was uncomfortable, the right side will be used.
Treatment groups
50 Participants
are divided into 1 treatment groupGroup A: SLN intervention group1 intervention
Trial outcomes
Primary outcomes
1
Change in score on the Leicester Cough Questionnaire
The Leicester Cough Questionnaire consists of 19 questions designed to assess the impact of cough on various aspects of a participant's quality of life. Scores are chosen from a Likert scale from 1 to 7, with 1 representing "all of the time" and 7 representing "none of the time." Scores would decrease if symptoms improved.
Time frame
Baseline to 3 monthsSponsors and contacts
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Source ClinicalTrials.gov