The Offspring Born to Mothers with Polycystic Ovary Syndrome in Guangzhou Cohort study (PCOS-BIG) was established to investigate the short- and long-term effects of intrauterine exposure to maternal PCOS on the health of offspring in Guangzhou, China. Data are collected regarding maternal PCOS subtypes, nursing, diet and education as well as health outcomes in their later life. Biological samples including blood and tissue samples are also collected from participants.
Offspring born to women diagnosed with PCOS
Offspring born to women with <20 weeks of gestation, intended to eventually deliver in Guangzhou Women and Children's Medical Center
Permanent residents or families intended to remain in Guangzhou for ≥3 years
None
Offspring born to women diagnosed with PCOS
Cohort
Prospective
Not listed
Number of Participants With Abnormal Laboratory Values (Glucolipid metabolism disorders)
Participants with one or more abnormal laboratory values will be considered as with glucolipid metabolism disorder.
Prevalence of gestational diabetes, pregnancy induced hypertension, and cesarean section
Assessed by self-reported time of onset and electronic medical records
Prevalence of stillbirth, preterm birth, small for gestational age, large for gestational age and birth defect
Assessed by electronic medical records
Epigenetic profiles of offspring
Profiling DNA methylation and histone acetylation etc., using cord blood samples
Weight changes
Weight changes from birth, to age of 6 weeks, 6 months, 1 year, 3 years, 6 years, 12 years and 18 years old
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Guangzhou Women and Children's Medical Center
Lead sponsor
University of Birmingham
Collaborator
