Health TrialsbyHealthPanel

Oklahoma Study of Native American Pain Risk III: Stress and Resilience

ConditionsDiscrimination, RacialStress PhysiologyPain
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Oklahoma

About this trial

The goal of this observational study is to learn about the relationship between environmental structural racism and discrimination and chronic pain risk in Native American adults. The main questions it aims to answer are:

1. How does environmental structural racism and discrimination affect chronic pain-promoting mechanisms in Native Americans? 2. What psychosocial factors buffer the negative effects of environmental structural racism and discrimination on chronic pain-promoting mechanisms?

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Self-identify as Native American/American Indian

Disqualifiers

<18 years of age

Self-reported history of cardiovascular, neuroendocrine, musculoskeletal, or neurological disorders

Surrent chronic pain, defined as persistent, bothersome pain on more days than not for at least 3 months)

Self-reported current substance dependence

Trial population

Participants will be adults who self-identify as Native American/American Indian.

Trial design

Design model

Cohort

Time perspective

Cross-sectional

Treatments tested in this trial

Not listed

Trial groups

220 Participants
are grouped into 1 trial group
Group A: Native Americans

Trial outcomes

Primary outcomes

1

Pain inhibition

Pain inhibition will be assessed using a conditioned pain modulation task with cold water as the conditioning stimulus and electric stimulations as the test stimulus.

Time frame
baseline
2

Inhibition of pain-related spinal reflex

Pain-related spinal reflex inhibition assessed from electromyogram will be assessed using a conditioned pain modulation task with cold water as the conditioning stimulus and electric stimulations as the test stimulus.

Time frame
baseline
3

Inhibition of pain-evoked cortical potentials

Inhibition of pain-evoked cortical potentials from electroencephalography will be assessed using a conditioned pain modulation task with cold water as the conditioning stimulus and electric stimulations as the test stimulus.

Time frame
baseline
4

Psychological stress

A single latent variable measuring psychological stress will be created using principal components analysis to combine scores from three self-report questionnaires: the Perceived Stress Scale (PSS), the Global Distress Index of the Symptom Checklist-90-Revised (SCL-90-R), and the PTSD Checklist-Civilian (PCL-C).

Time frame
baseline

Secondary outcomes

1

Temporal summation of pain

Temporal summation of pain will be measured by assessing the change in a participant's pain ratings in response identical noxious stimuli delivered in rapid succession.

Time frame
baseline
2

Temporal summation of spinal nociception

Temporal summation of spinal nociception will be measured by assessing the change in a participant's pain-related reflex magnitude (assessed from electromyography) in response identical noxious stimuli delivered in rapid succession.

Time frame
baseline
3

Pain tolerance

Pain tolerance will be measured with ischemic and cold pain tasks. Participants will continuously rate their pain in response to painful tonic stimuli, and pain tolerance will be quantified as the time (in seconds) that it takes for participants to report that they can no longer tolerate the pain.

Time frame
basline

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Oklahoma

Lead sponsor

Oklahoma State University

Collaborator

University of Tulsa

Collaborator

Source ClinicalTrials.gov
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