Health TrialsbyHealthPanel

Olfactory Dysfunction in Aging Adults

ConditionOlfactory Dysfunction
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age50+
SponsorMedical University of South Carolina

About this trial

This prospective longitudinal cohort study will enroll adults aged 50 years and older to characterize olfactory dysfunction in aging. Participants will undergo comprehensive olfactory testing, cognitive assessment, biomarker collection, and imaging to identify clinically relevant phenotypes based on anatomic site of dysfunction. The study will also evaluate the impact of olfactory dysfunction on quality of life and identify baseline factors associated with changes in olfactory function over time.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Age: 50 years or older

Ability to follow instructions and understand consent process in English

Adequate visual, auditory, or motor functioning to complete items in the test battery or availability of assistance or assist devices to complete tasks

Disqualifiers

None

Trial population

Community-dwelling adults aged 50 years and older recruited from the Medical University of South Carolina (MUSC) and surrounding community, including clinic patients and individuals responding to advertisements, who may have normal olfactory function or varying degrees of olfactory dysfunction.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Clinical and Biomarker Assessments

    Other intervention

    Participants undergo olfactory testing (Sniffin' Sticks), cognitive assessment, nasal endoscopy, olfactory mucus collection, MRI imaging (subset), and patient-reported outcome measures to evaluate olfactory function, biomarkers, and health outcomes over time.

Treatment groups

500 Participants
are divided into 1 treatment group
Group A: Older Adults With and Without Olfactory Dysfunction1 intervention

Trial outcomes

Primary outcomes

1

Olfactory Function

Olfactory Threshold, Discrimination, and Identification (TDI scores) using Sniffin' Sticks.

Time frame
Baseline

Secondary outcomes

1

Change in Olfactory Function Over Time

Longitudinal assessment of changes in olfactory function to identify decline over time.. Change in TDI scores (threshold, discrimination, identification)

Time frame
Year 1 and year 2
2

Patient-Reported Outcomes

Patient-reported measure assessing quality of life using QOD questionnaire.

Time frame
Baseline, Year 1 and year 2

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Medical University of South Carolina

Lead sponsor

National Institute on Deafness and Other Communication Disorders (NIDCD)

Collaborator

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: