Olfactory Training on Smell Dysfunction Patients in HK

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorPamela Youde Nethersole Eastern Hospital

About this trial

* Causes of olfactory dysfunction can be classified into conductive and sensorineural causes. * Conductive causes are mainly due to structural nasal problem, which can be treated by nasal surgery * Sensorineural causes included post-infection, post-head injury, post Head and Neck irradiation and other central nervous system diseases. * Olfactory Training is well established treatment for sensorineural olfactory dysfunction in foreign countries. * Olfactory Training by neurological chemosensory stimulation using aromatic substances delivered via electronic portable aromatic rehabilitation (EPAR) diffuser was proved to be effective treatment in COVID-19 related olfactory dysfunction in recent Hong Kong study. * However, there is a lack of local study on the effect of Olfactory Training in other non-COVID-19 sensorineural causes of olfactory dysfunction in Hong Kong population.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Olfactory dysfunction > 6 months and < 5 years

Disqualifiers

History of significant head injury (fracture, ICH)

History of brain surgery

History of nasal surgery

Active nasal disease

Trial design

Design model

Parallel

Treatments tested in this trial

  • Olfactory Training

    Other intervention

    Four aromatic substances will be used (Citrus limon, Eucalyptus radiata, Pelargonium graveolens, Juniperus virginiana)

  • Control

    Other intervention

    Normal Saline will be used

Treatment groups

80 Participants
are divided into 2 treatment groups
Group A: Treatment armExperimental treatment 1 intervention
Group B: Control armPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Olfactory threshold changes after olfactory training after 3 months

Parameter: Olfactory threshold using Butanol Threshold Test (BTT)

Time frame
3 months after starting smell training
2

Olfactory identification score changes after olfactory training after 3 months

Parameter: Olfactory identification using Smell Identification Test (UPSIT)

Time frame
3 months after starting smell training
3

Quality of life changes after olfactory training after 3 months

Parameter: Subjective quality of life score using Sino-Nasal Outcome Test (SNOT-22)

Time frame
3 months after starting smell training
4

Taste and smell changes after olfactory training after 3 months

Parameter: Subjective smell and taste assessment using Visual Analogue Scale (VAS)

Time frame
3 months after starting smell training

Secondary outcomes

Other outcomes

Sponsors and contacts

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