Using RBS as the navigation and treatment platform, precisely navigate to the target lesion. Utilize r-EUBS and nCLE to identify the lesion, and when the confocal AI model recognizes the lesion as malignant, perform a biopsy. Subsequently, under the guidance of OBCT, carry out ablation treatment of the lesion.
Age ≥18 years, male or female.
High-risk pulmonary nodule/tumor maximum diameter ≤3 cm.
Lesion judged suitable for bronchial navigation-guided diagnosis and treatment.
Ineligible for surgery or refuses surgery/radiotherapy; agrees to primary ablation therapy; provides written informed consent.
Diffuse bilateral lung lesions unresponsive to ablation.
Contraindication to bronchoscopy or inability to tolerate/cooperate with bronchoscopy.
Severe bleeding tendency or irreversible coagulopathy (PT >18 s, PTA <40%).Platelet count <70×10⁹/L; anticoagulant/antiplatelet therapy discontinued <1 week before ablation (except prophylactic low-molecular-weight heparin).
Severe pulmonary impairment (maximal voluntary ventilation <40%).
Single group
Ablation
Procedure/SurgeryUsing RBS, nCLE, r-EBUS, OBCT and Cryoablation or Radiofrequency ablation for lung cancer
Integrated completion rate of detection, sampling and treatment
Integrated completion rate of detection, sampling and treatment= (Number of cases with successful integrated detection, sampling and treatment / Total enrolled cases) × 100% Definition of integrated success: Under the guidance of the bronchial navigation and positioning system, the lesion is confirmed by radial endobronchial ultrasound (r-EBUS) or CBCT; imaging diagnosis is obtained via probe-based confocal laser endomicroscopy (pCLE); qualified tissue samples are successfully collected; and local treatment is completed.
Diagnostic success rate
Diagnostic success rate = (Number of cases with definite pathological diagnosis / Total enrolled cases) × 100% Definition of definite pathological diagnosis: Malignant lesions Specific benign lesions: tuberculosis, fungal infection, granulomatous lesions, organizing pneumonia, etc.
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