The goal of this observational study is to evaluate the association between post-coronary angiography IMR and medium-term clinical prognosis in patients with acute myocarditis. The main question it aims to answer is:
Is there a correlation between impaired microcirculation and the occurrence of serious clinical events in this population of patients?
Male or female patients over the age of 18.
Patients hospitalized between June 2015 and July 2025.
Electrocardiographic abnormalities (ST-segment elevation or depression, T-wave inversions, conduction disturbances such as type 3 atrioventricular block),
Elevated troponin levels,
Absence of coronary artery disease confirmed by coronary angiography
Myocarditis secondary to immunotherapy
Presence of documented coronary artery disease (coronary angiography or cardiac CT)
Presence of cardiomyopathy (hypertrophic cardiomyopathy, dilated cardiomyopathy)
patients hospitalized in the cardiology department at CHUGA between 2015 and 2025 who had a diagnosis of myocarditis confirmed by cardiac MRI.
Cohort
Retrospective
Coronary catheterization
Procedure/SurgeryCoronary catheterization
MACE
The primary endpoint is the 1-year incidence rate of MACE. MACE is defined by a composite endpoint comprising: 1) all-cause mortality, 2) cardiac decompensation requiring readmission, 3) heart transplantation, 4) documented sustained ventricular arrhythmia lasting \>30 seconds, and 5) recurrence of myocarditis.
Individual components of the 12-month MACE: cardiovascular death, transplantation, hospitalization for heart failure, and persistent heart failure (reported separately)
Correlation between IMR angiographic NH (continuous variable) and: a) MRI imaging criteria (LVEF, fibrosis, septal involvement, edema); b) biological markers (maximum troponin, CRP)
Predictive value of MRI angiography: diagnostic performance in predicting the primary endpoint (ROC, optimal cut-off values, sensitivity/specificity)
Assessment of inter- and intra-observer reproducibility of the MR angiography NH calculation (if a subsample is reanalyzed)
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