OCT-A and eco-colordoppler are technologies which enable optic nerve head (ONH) blood perfusion detection. The aim of the study is to assess ONH vascular and structural components in optic neuropathies with and without ONH edema or pseudo-edema with OCT-A, and analyze ONH blood-flow with eco-colordoppler.
Participant (or parents/legal representative/tutor for minors) is willing and able to give informed consent for participation in the study
patients affected by acute ONH edema (NAION, papilledema, optic neuritis)
patients affected by acute pseudoedema (LHON)
patients affected by chronic pseudoedema (LHON, ODD)
any other ONH disease or neurological /retinal disease impairing the evaluation of the ONH;
evidence of media opacities affecting the quality of the vascular assessment;
patients affected Alzheimer/Parkinson disease will be considered separately
Patients aged ≥12 years affected with non-arteritic ischemic optic neuropathy (NAION, eye involved and not involved), normal tension glaucoma (NTG), Leber hereditary optic neuropathy (LHON symptomatic and asymptomatic patients \[carriers\]), anterior neuritis \[papillitis\], papilledema, optic disc drusen (ODD), dominant optic atrophy (DOA) and Wolfram Syndrome (WS)
Other
Prospective
Not listed
Parameters correlated to the development and progression (prognostic biomarkers) of the diseases.
Analysis of data collected in symptomatic and asymptomatic eyes, obtained through OCT-A in order to evaluate the relationship between functional and structural parameters in order to identify parameters correlated to the development and progression of the diseases.
To assess and compare different ONH vascular components through OCT-A and eco-colordoppler in order to identify parameters correlated to the diseases.
To detect OCT-A parameters (vessel density, perfusion density), and eco-colordoppler parameters of central retina artery (CRA) and short posterior ciliary artery (SPCA) (systolic and diastolic flow and resistance). in order to evaluate their relationship in each optic neuropathy.
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Barboni
Lead sponsor
IRCCS San Raffaele
Sponsor institution
Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Collaborator
ASST Fatebenefratelli Sacco
Collaborator
This trial is not recruiting at the moment. You can still explore other options:
