Optimization of ITBS for Depression
ConditionNeuromodulation
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-35
SponsorUniversité de Sherbrooke
About this trial
Repetitive TMS (rTMS) is a well-established method for modulating brain activity. Through successive stimulations in the form of magnetic fields, it is possible to modify the sensitivity of neurons in the brain, also known as cortical excitability. Cortical excitability is important for the induction of brain plasticity, the ability of the brain to reorganize itself and form new connections in response to stimuli. A particular class of rTMS, intermittent theta burst TMS (iTBS), is commonly used to modulate cortical excitability and induce plasticity for therapeutic purposes, notably for treatment-resistant depression.
Different iTBS stimulation parameters can be used to induce plasticity. This study will focus on two parameters, namely, the form and duration of the electromagnetic stimulation. The shape of the electromagnetic pulse refers to how the electromagnetic wave is configured over time, while the duration is simply the period during which this electromagnetic pulse remains active. These parameters are expected to influence the effectiveness of iTBS in modulating cortical activity but remain little studied.
The main aim of this study will be to compare the effectiveness of different stimulation parameters in the induction of plasticity, which will then make it possible to improve the rTMS protocols used for treatment-resistant depression.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Be between 18 and 35 years old
Be of right manual dominance
In good health
Disqualifiers
Have an implant or pacemaker,
Having tinnitus,
Have a history of fainting,
Have already had an epileptic seizure or have a family history of epilepsy,
Trial design
Design model
Single group
Treatments tested in this trial
Monophasic iTBS
DeviceiTBS protocol with monophasic-shaped pulses. iTBS parameters: * Intensity: 80% of resting motor threshold (rMT) * Frequency: 50 Hz * Duration of pulse train: 2 seconds * Interval between pulse trains: 8 seconds
Biphasic iTBS
DeviceiTBS protocol with biphasic-shaped pulses. iTBS parameters: * Intensity: 80% of rMT * Frequency: 50 Hz * Duration of pulse train: 2 seconds * Interval between pulse trains: 8 seconds
Monophasic-Long iTBS
DeviceiTBS protocol with long monophasic-shaped pulses. iTBS parameters: * Intensity: 80% of rMT * Frequency: 50 Hz * Duration of pulse train: 2 seconds * Interval between pulse trains: 8 seconds
Treatment groups
30 Participants
are divided into 1 treatment groupGroup A: Intermittent theta burst stimulation (iTBS)Experimental treatment 3 interventions
Trial outcomes
Primary outcomes
1
TMS derived measure of cortical plasticity
Change in Peak-to-peak motor evoked potential (MEP) amplitude induced by the administration of the test stimulus (stimulation intensity required to produce an MEP of 1 millivolt, approximately 120% of rMT) after iTBS
Time frame
Pre-iTBS, Every 5 minutes post iTBS intervention up to 60 minutes post intervention.Sponsors and contacts
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Source ClinicalTrials.gov